Anti-isthmus autoimmunity in a novel feline acquired alopecia resembling pseudopelade of humans

Thierry Olivry, Helen T. Power, Jennifer C. Woo, Peter F Moore, Desmond J. Tobin

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Pseudopelade is a primary scarring (cicatricial) alopecia of humans characterized by lymphocyte-rich inflammation centred around the hair follicle isthmus. Lymphocyte folliculotropism is associated with isthmus apoptosis and, ultimately, follicular destruction and dermal fibrosis. In a cat, an acquired alopecia was diagnosed as pseudopelade based on the following criteria: (i) an adult-onset, patchy to diffuse nonpruritic hair loss; (ii) an early folliculo-destructive phase in which lymphocytes and dendritic cells accumulated in and around the follicular isthmus; and (iii) a late stage in which the lower segments of hair follicles underwent atrophy and were replaced by fibrosing tracts. Additionally, immunological investigations characterized the cytotoxic phenotype of isthmotropic lymphocytes and demonstrated the presence of circulating IgG autoantibodies specific for multiple follicular antigens. Altogether, the results of the present study suggest an immune-mediated pathogenesis for this case of feline pseudopelade, similarly to that causing alopecia areata in humans and other mammalian species.

Original languageEnglish (US)
Pages (from-to)261-270
Number of pages10
JournalVeterinary Dermatology
Volume11
Issue number4
StatePublished - Dec 2000

Fingerprint

autoimmunity
alopecia
Alopecia
Felidae
Autoimmunity
lymphocytes
cats
hair follicles
Lymphocytes
Hair Follicle
autoantibodies
dendritic cells
atrophy
fibrosis
Alopecia Areata
pathogenesis
apoptosis
inflammation
antigens
phenotype

Keywords

  • Alopecia areata
  • Antifollicular autoantibodies
  • Autoimmunity
  • Cat
  • Cicatricial alopecia
  • Pseudopelade

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Anti-isthmus autoimmunity in a novel feline acquired alopecia resembling pseudopelade of humans. / Olivry, Thierry; Power, Helen T.; Woo, Jennifer C.; Moore, Peter F; Tobin, Desmond J.

In: Veterinary Dermatology, Vol. 11, No. 4, 12.2000, p. 261-270.

Research output: Contribution to journalArticle

Olivry, Thierry ; Power, Helen T. ; Woo, Jennifer C. ; Moore, Peter F ; Tobin, Desmond J. / Anti-isthmus autoimmunity in a novel feline acquired alopecia resembling pseudopelade of humans. In: Veterinary Dermatology. 2000 ; Vol. 11, No. 4. pp. 261-270.
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