Anti-collagen Autoantibodies are Found in Women with Silicone Breast Implants

Suzanne S Teuber, Merrill J. Rowley, Steven H. Yoshida, Aftab A. Ansari, M. Eric Gershwin

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

There have been several anecdotal reports that silicone breast implants are associated with an increased incidence of autoimmune disease. Based upon these data as well as the theoretical potential of silicon and silicone immune interactions, we hypothesized that an immune response to a silicone breast implant would include host reactivity against components of the microenvironment within the implant milieu. To test this hypothesis, we obtained detailed histories and performed examinations of 57 consecutive, self-referred patients concerned about their breast implants. Eleven of these women were excluded for various reasons including previous exposure to bovine collagen. The remaining 46 women, as well as 45 normal women of approximately the same age and living in the same geographic region, were tested using a sensitive ELISA for the presence of autoantibodies to human native type I collagen, denatured type I collagen, native type II collagen and denatured type II collagen. Known positive and negative sera were included in all assays and the ELISA was performed and interpreted blindly. Positive sera were defined as an ELISA value of three standard deviations above the mean of the normal controls. Using these stringent criteria, there was a statistically significant incidence of antibodies to collagen in women with silicone breast implants. In fact, 35% of women with silicone breast implants had such antibodies; this is higher than we have observed in any other autoimmune disease and is similar to that of chronic erosive rheumatoid arthritis. We believe that silicone breast implants, in genetically susceptible hosts, may pose a significant risk for immunopathology.

Original languageEnglish (US)
Pages (from-to)367-377
Number of pages11
JournalJournal of Autoimmunity
Volume6
Issue number3
DOIs
StatePublished - Jun 1993

Fingerprint

Breast Implants
Silicones
Autoantibodies
Collagen
Collagen Type II
Enzyme-Linked Immunosorbent Assay
Autoimmune Diseases
Antibodies
Incidence
Silicon
Collagen Type I
Serum
Rheumatoid Arthritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Anti-collagen Autoantibodies are Found in Women with Silicone Breast Implants. / Teuber, Suzanne S; Rowley, Merrill J.; Yoshida, Steven H.; Ansari, Aftab A.; Gershwin, M. Eric.

In: Journal of Autoimmunity, Vol. 6, No. 3, 06.1993, p. 367-377.

Research output: Contribution to journalArticle

Teuber, Suzanne S ; Rowley, Merrill J. ; Yoshida, Steven H. ; Ansari, Aftab A. ; Gershwin, M. Eric. / Anti-collagen Autoantibodies are Found in Women with Silicone Breast Implants. In: Journal of Autoimmunity. 1993 ; Vol. 6, No. 3. pp. 367-377.
@article{9767a848ebf441808b08f0657fa9367a,
title = "Anti-collagen Autoantibodies are Found in Women with Silicone Breast Implants",
abstract = "There have been several anecdotal reports that silicone breast implants are associated with an increased incidence of autoimmune disease. Based upon these data as well as the theoretical potential of silicon and silicone immune interactions, we hypothesized that an immune response to a silicone breast implant would include host reactivity against components of the microenvironment within the implant milieu. To test this hypothesis, we obtained detailed histories and performed examinations of 57 consecutive, self-referred patients concerned about their breast implants. Eleven of these women were excluded for various reasons including previous exposure to bovine collagen. The remaining 46 women, as well as 45 normal women of approximately the same age and living in the same geographic region, were tested using a sensitive ELISA for the presence of autoantibodies to human native type I collagen, denatured type I collagen, native type II collagen and denatured type II collagen. Known positive and negative sera were included in all assays and the ELISA was performed and interpreted blindly. Positive sera were defined as an ELISA value of three standard deviations above the mean of the normal controls. Using these stringent criteria, there was a statistically significant incidence of antibodies to collagen in women with silicone breast implants. In fact, 35{\%} of women with silicone breast implants had such antibodies; this is higher than we have observed in any other autoimmune disease and is similar to that of chronic erosive rheumatoid arthritis. We believe that silicone breast implants, in genetically susceptible hosts, may pose a significant risk for immunopathology.",
author = "Teuber, {Suzanne S} and Rowley, {Merrill J.} and Yoshida, {Steven H.} and Ansari, {Aftab A.} and Gershwin, {M. Eric}",
year = "1993",
month = "6",
doi = "10.1006/jaut.1993.1031",
language = "English (US)",
volume = "6",
pages = "367--377",
journal = "Journal of Autoimmunity",
issn = "0896-8411",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Anti-collagen Autoantibodies are Found in Women with Silicone Breast Implants

AU - Teuber, Suzanne S

AU - Rowley, Merrill J.

AU - Yoshida, Steven H.

AU - Ansari, Aftab A.

AU - Gershwin, M. Eric

PY - 1993/6

Y1 - 1993/6

N2 - There have been several anecdotal reports that silicone breast implants are associated with an increased incidence of autoimmune disease. Based upon these data as well as the theoretical potential of silicon and silicone immune interactions, we hypothesized that an immune response to a silicone breast implant would include host reactivity against components of the microenvironment within the implant milieu. To test this hypothesis, we obtained detailed histories and performed examinations of 57 consecutive, self-referred patients concerned about their breast implants. Eleven of these women were excluded for various reasons including previous exposure to bovine collagen. The remaining 46 women, as well as 45 normal women of approximately the same age and living in the same geographic region, were tested using a sensitive ELISA for the presence of autoantibodies to human native type I collagen, denatured type I collagen, native type II collagen and denatured type II collagen. Known positive and negative sera were included in all assays and the ELISA was performed and interpreted blindly. Positive sera were defined as an ELISA value of three standard deviations above the mean of the normal controls. Using these stringent criteria, there was a statistically significant incidence of antibodies to collagen in women with silicone breast implants. In fact, 35% of women with silicone breast implants had such antibodies; this is higher than we have observed in any other autoimmune disease and is similar to that of chronic erosive rheumatoid arthritis. We believe that silicone breast implants, in genetically susceptible hosts, may pose a significant risk for immunopathology.

AB - There have been several anecdotal reports that silicone breast implants are associated with an increased incidence of autoimmune disease. Based upon these data as well as the theoretical potential of silicon and silicone immune interactions, we hypothesized that an immune response to a silicone breast implant would include host reactivity against components of the microenvironment within the implant milieu. To test this hypothesis, we obtained detailed histories and performed examinations of 57 consecutive, self-referred patients concerned about their breast implants. Eleven of these women were excluded for various reasons including previous exposure to bovine collagen. The remaining 46 women, as well as 45 normal women of approximately the same age and living in the same geographic region, were tested using a sensitive ELISA for the presence of autoantibodies to human native type I collagen, denatured type I collagen, native type II collagen and denatured type II collagen. Known positive and negative sera were included in all assays and the ELISA was performed and interpreted blindly. Positive sera were defined as an ELISA value of three standard deviations above the mean of the normal controls. Using these stringent criteria, there was a statistically significant incidence of antibodies to collagen in women with silicone breast implants. In fact, 35% of women with silicone breast implants had such antibodies; this is higher than we have observed in any other autoimmune disease and is similar to that of chronic erosive rheumatoid arthritis. We believe that silicone breast implants, in genetically susceptible hosts, may pose a significant risk for immunopathology.

UR - http://www.scopus.com/inward/record.url?scp=0027244268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027244268&partnerID=8YFLogxK

U2 - 10.1006/jaut.1993.1031

DO - 10.1006/jaut.1993.1031

M3 - Article

C2 - 8397717

AN - SCOPUS:0027244268

VL - 6

SP - 367

EP - 377

JO - Journal of Autoimmunity

JF - Journal of Autoimmunity

SN - 0896-8411

IS - 3

ER -