Anti-chemotactic activities of peptide-T: A possible mechanism of actions for its therapeutic effects on psoriasis

Smriti K. Raychaudhuri, Siba P Raychaudhuri, Eugene M. Farber

Research output: Contribution to journalArticle

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Abstract

Peptide T is an octapeptide (ASTTTNYT) from the V2 region of gp120 of HIV. D-[Ala]-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-amide (DAPTA) is one of its analogue. DAPTA has been shown to resolve the psoriatic lesions. The mechanisms of action of peptide T for its therapeutic effect is not clearly understood. Lymphomononuclear cells play an important roles in inflammatory disease processes. Intraepidermal collection of lymphocytes is a unique feature of the inflammatory processes of psoriasis. It is believed that chemokine such as RANTES (C-C class) plays an important role for intraepidermal localization of the inflammatory infiltrates in psoriasis. In order to study the mechanisms, we have analyzed the effects of DAPTA on monocyte and lymphocyte chemotaxis. Chemotaxis of cells was measured by using Boyden chamber. DAPTA inhibited significantly the monocyte and lymphocyte chemotactic activity of RANTES ( p < 0.005, <0.001). Antichemotactic activities of peptide T analogue could be a possible explanation for its therapeutic efficacy in psoriasis. Copyright (C) 1998 International Society for Immunopharmacology. Published by Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)661-667
Number of pages7
JournalInternational Journal of Immunopharmacology
Volume20
Issue number11
DOIs
StatePublished - Dec 2 1998
Externally publishedYes

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Keywords

  • Anti-inflammatory actions
  • Peptide T
  • Psoriasis

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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