Abstract
Peptide T is an octapeptide (ASTTTNYT) from the V2 region of gp120 of HIV. D-[Ala]-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-amide (DAPTA) is one of its analogue. DAPTA has been shown to resolve the psoriatic lesions. The mechanisms of action of peptide T for its therapeutic effect is not clearly understood. Lymphomononuclear cells play an important roles in inflammatory disease processes. Intraepidermal collection of lymphocytes is a unique feature of the inflammatory processes of psoriasis. It is believed that chemokine such as RANTES (C-C class) plays an important role for intraepidermal localization of the inflammatory infiltrates in psoriasis. In order to study the mechanisms, we have analyzed the effects of DAPTA on monocyte and lymphocyte chemotaxis. Chemotaxis of cells was measured by using Boyden chamber. DAPTA inhibited significantly the monocyte and lymphocyte chemotactic activity of RANTES ( p < 0.005, <0.001). Antichemotactic activities of peptide T analogue could be a possible explanation for its therapeutic efficacy in psoriasis. Copyright (C) 1998 International Society for Immunopharmacology. Published by Elsevier Science Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 661-667 |
| Number of pages | 7 |
| Journal | International Journal of Immunopharmacology |
| Volume | 20 |
| Issue number | 11 |
| DOIs | |
| State | Published - Dec 2 1998 |
| Externally published | Yes |
Fingerprint
Keywords
- Anti-inflammatory actions
- Peptide T
- Psoriasis
ASJC Scopus subject areas
- Immunology
- Pharmacology
Cite this
Anti-chemotactic activities of peptide-T : A possible mechanism of actions for its therapeutic effects on psoriasis. / Raychaudhuri, Smriti K.; Raychaudhuri, Siba P; Farber, Eugene M.
In: International Journal of Immunopharmacology, Vol. 20, No. 11, 02.12.1998, p. 661-667.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anti-chemotactic activities of peptide-T
T2 - A possible mechanism of actions for its therapeutic effects on psoriasis
AU - Raychaudhuri, Smriti K.
AU - Raychaudhuri, Siba P
AU - Farber, Eugene M.
PY - 1998/12/2
Y1 - 1998/12/2
N2 - Peptide T is an octapeptide (ASTTTNYT) from the V2 region of gp120 of HIV. D-[Ala]-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-amide (DAPTA) is one of its analogue. DAPTA has been shown to resolve the psoriatic lesions. The mechanisms of action of peptide T for its therapeutic effect is not clearly understood. Lymphomononuclear cells play an important roles in inflammatory disease processes. Intraepidermal collection of lymphocytes is a unique feature of the inflammatory processes of psoriasis. It is believed that chemokine such as RANTES (C-C class) plays an important role for intraepidermal localization of the inflammatory infiltrates in psoriasis. In order to study the mechanisms, we have analyzed the effects of DAPTA on monocyte and lymphocyte chemotaxis. Chemotaxis of cells was measured by using Boyden chamber. DAPTA inhibited significantly the monocyte and lymphocyte chemotactic activity of RANTES ( p < 0.005, <0.001). Antichemotactic activities of peptide T analogue could be a possible explanation for its therapeutic efficacy in psoriasis. Copyright (C) 1998 International Society for Immunopharmacology. Published by Elsevier Science Ltd.
AB - Peptide T is an octapeptide (ASTTTNYT) from the V2 region of gp120 of HIV. D-[Ala]-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-amide (DAPTA) is one of its analogue. DAPTA has been shown to resolve the psoriatic lesions. The mechanisms of action of peptide T for its therapeutic effect is not clearly understood. Lymphomononuclear cells play an important roles in inflammatory disease processes. Intraepidermal collection of lymphocytes is a unique feature of the inflammatory processes of psoriasis. It is believed that chemokine such as RANTES (C-C class) plays an important role for intraepidermal localization of the inflammatory infiltrates in psoriasis. In order to study the mechanisms, we have analyzed the effects of DAPTA on monocyte and lymphocyte chemotaxis. Chemotaxis of cells was measured by using Boyden chamber. DAPTA inhibited significantly the monocyte and lymphocyte chemotactic activity of RANTES ( p < 0.005, <0.001). Antichemotactic activities of peptide T analogue could be a possible explanation for its therapeutic efficacy in psoriasis. Copyright (C) 1998 International Society for Immunopharmacology. Published by Elsevier Science Ltd.
KW - Anti-inflammatory actions
KW - Peptide T
KW - Psoriasis
UR - http://www.scopus.com/inward/record.url?scp=0032477295&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032477295&partnerID=8YFLogxK
U2 - 10.1016/S0192-0561(98)00020-4
DO - 10.1016/S0192-0561(98)00020-4
M3 - Article
VL - 20
SP - 661
EP - 667
JO - International Immunopharmacology
JF - International Immunopharmacology
SN - 1567-5769
IS - 11
ER -