Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation

G. Vlad, E. K. Ho, E. R. Vasilescu, J. Fan, Z. Liu, J. W. Cai, Z. Jin, E. Burke, M. Deng, M. Cadeiras, R. Cortesini, S. Itescu, C. Marboe, D. Mancini, N. Suciu-Foca

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The interleukin-2 receptor alpha chain (IL-2Ra, CD25) plays a major part in shaping the dynamics of T cell populations following immune activation, due to its role in T cell proliferation and survival. Strategies to blunt the effector responses in transplantation have been developed by devising pharmaceutical agents to block the IL-2 pathways. However, such strategies could adversely affect the CD25+FOXP3+T regulatory (T reg) populations which also rely on intereukin-2 signaling for survival. The present study shows that a cohort of heart allograft recipients treated with Daclizumab (a humanized anti-CD25 antibody) display FOXP3 expression patterns consistent with functional T regulatory cell populations. High levels of FOXP3 were observed to correlate with lower incidence of and recovery from acute rejection, as well as lower levels of anti-donor HLA antibody production. Therefore, T reg populations appear fully functional in patients treated with Daclizumab, even when 5 doses were administered. By comparison, patients treated with fewer doses or no Daclizumab had a higher incidence of acute rejection, antibody production and graft failure. Therefore, our data indicates that Daclizumab treatment does not interfere with the generation of regulatory T cells and has a beneficial effect on heart allograft survival.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalTransplant Immunology
Volume18
Issue number1
DOIs
StatePublished - Jul 1 2007
Externally publishedYes

Keywords

  • Daclizumab
  • FOXP3
  • Heart transplantation
  • Rejection
  • T regulatory cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Transplantation

Fingerprint Dive into the research topics of 'Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation'. Together they form a unique fingerprint.

  • Cite this

    Vlad, G., Ho, E. K., Vasilescu, E. R., Fan, J., Liu, Z., Cai, J. W., Jin, Z., Burke, E., Deng, M., Cadeiras, M., Cortesini, R., Itescu, S., Marboe, C., Mancini, D., & Suciu-Foca, N. (2007). Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation. Transplant Immunology, 18(1), 13-21. https://doi.org/10.1016/j.trim.2007.03.001