Abstract
Toll-like receptors induce innate immune responses recognizing conserved microbial structural molecules that are known as pathogen-associated molecular patterns (PAMPs). Ligand-induced homotypic oligomerization was fond to proceed in LPS-induced activation of TLR4 signaling pathways. TLR2 is known to heterodimerize with TLRI or TLR6 and recognize diacyl-or triacyl-lipopeptide, respectively. These results suggest that ligand-induced receptor dimerization of TLR4 and TLR2 is required for the activation of downstream signaling pathways. Therefore, receptor dimerezation may be one of the first lines of regulation in the activation of TLR-mediated signaling pathways and induction of subsequent inhibits activation of NF-κB, expression of COX-2 and dimerization of TLRs induced by TLR2, TLR3 and TLR4 agonists. These results imply that curcumin can modulate the activation of TLR and subsequent immune/inflammatory responses induced by microbial pathogens.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 175-180 |
| Number of pages | 6 |
| Journal | Korean Journal of Food Science and Technology |
| Volume | 39 |
| Issue number | 2 |
| State | Published - 2007 |
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Keywords
- Curcumin
- LPS
- MALP-2
- MyD88
- Poly [I:C]
- Toll-like receptors
- TRIF
ASJC Scopus subject areas
- Food Science
- Biotechnology
- Applied Microbiology and Biotechnology
Cite this
Anti-cancer and anti-inflammatory effects of curcumin by the modulation of Toll-like Receptor 2, 3 and 4. / Youn, Hyung Sun; Ah Kang, Soon; Hwang, Daniel.
In: Korean Journal of Food Science and Technology, Vol. 39, No. 2, 2007, p. 175-180.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anti-cancer and anti-inflammatory effects of curcumin by the modulation of Toll-like Receptor 2, 3 and 4
AU - Youn, Hyung Sun
AU - Ah Kang, Soon
AU - Hwang, Daniel
PY - 2007
Y1 - 2007
N2 - Toll-like receptors induce innate immune responses recognizing conserved microbial structural molecules that are known as pathogen-associated molecular patterns (PAMPs). Ligand-induced homotypic oligomerization was fond to proceed in LPS-induced activation of TLR4 signaling pathways. TLR2 is known to heterodimerize with TLRI or TLR6 and recognize diacyl-or triacyl-lipopeptide, respectively. These results suggest that ligand-induced receptor dimerization of TLR4 and TLR2 is required for the activation of downstream signaling pathways. Therefore, receptor dimerezation may be one of the first lines of regulation in the activation of TLR-mediated signaling pathways and induction of subsequent inhibits activation of NF-κB, expression of COX-2 and dimerization of TLRs induced by TLR2, TLR3 and TLR4 agonists. These results imply that curcumin can modulate the activation of TLR and subsequent immune/inflammatory responses induced by microbial pathogens.
AB - Toll-like receptors induce innate immune responses recognizing conserved microbial structural molecules that are known as pathogen-associated molecular patterns (PAMPs). Ligand-induced homotypic oligomerization was fond to proceed in LPS-induced activation of TLR4 signaling pathways. TLR2 is known to heterodimerize with TLRI or TLR6 and recognize diacyl-or triacyl-lipopeptide, respectively. These results suggest that ligand-induced receptor dimerization of TLR4 and TLR2 is required for the activation of downstream signaling pathways. Therefore, receptor dimerezation may be one of the first lines of regulation in the activation of TLR-mediated signaling pathways and induction of subsequent inhibits activation of NF-κB, expression of COX-2 and dimerization of TLRs induced by TLR2, TLR3 and TLR4 agonists. These results imply that curcumin can modulate the activation of TLR and subsequent immune/inflammatory responses induced by microbial pathogens.
KW - Curcumin
KW - LPS
KW - MALP-2
KW - MyD88
KW - Poly [I:C]
KW - Toll-like receptors
KW - TRIF
UR - http://www.scopus.com/inward/record.url?scp=79959434734&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959434734&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:79959434734
VL - 39
SP - 175
EP - 180
JO - Korean Journal of Food Science and Technology
JF - Korean Journal of Food Science and Technology
SN - 0367-6293
IS - 2
ER -