Abstract
The aim of this study was to relate placental transfer, quantified by the cord to maternal serum concentration ratio (C/M), of five organochlorine pesticides (OCP) hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), γ-hexachlorocyclohexane (γ-HCH), p,p'-DDT, p,p'-DDE and 15 polychlorinated biphenyl (PCB) congeners (28, 52, 101, 105, 114, 118, 123+149, 138+163, 153, 156+171, 157, 167, 170, 180, and 189) to anthropometric, socioeconomic, and maternal health characteristics. We included into the study 1,134 births during the period 2002-2004 from two districts in eastern Slovakia with high organochlorine concentrations relative to other areas of the world. Only concentrations >LOD were taken into account. Variables as age, weight and height of mothers, parity, ethnicity, alcohol consumption, illness during pregnancy, smoking during pregnancy, hypertension, respiratory diseases, rheumatoid arthritis and diabetes mellitus, and birth weight were related to C/M. Results of regression analyses showed that C/M was predicted by several factors studied. Positive associations were observed for gestational alcohol consumption, fewer illnesses during pregnancy, maternal age, and maternal weight. Caucasians had a greater C/M compared to Romani for wet weight data of congeners 170 and 180 and in contrast C/M for HCB was greater in Romani. Our results show that drinking mothers compared to abstaining expose their fetuses not only to alcohol but to an increased level of several PCB congeners. A straightforward explanation of associations between C/M shifts and factors studied is very difficult, however, with regard to the high lipophilicity of OCPs and PCBs, changes in their kinetics probably reflect lipid kinetics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8557-8566 |
| Number of pages | 10 |
| Journal | Environmental Science and Pollution Research |
| Volume | 20 |
| Issue number | 12 |
| DOIs | |
| State | Published - 2013 |
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Keywords
- Alcohol
- Organochlorine pesticides
- PCB
- Placental transfer
ASJC Scopus subject areas
- Environmental Chemistry
- Health, Toxicology and Mutagenesis
- Pollution
Cite this
Anthropometric, socioeconomic, and maternal health determinants of placental transfer of organochlorine compounds. / Patayová, Henrieta; Wimmerová, Soňa; Lancz, Kinga; Palkovičová, Ľubica; Drobná, Beata; Fabišiková, Anna; Kováč, Ján; Hertz-Picciotto, Irva; Jusko, Todd A.; Trnovec, Tomáš.
In: Environmental Science and Pollution Research, Vol. 20, No. 12, 2013, p. 8557-8566.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anthropometric, socioeconomic, and maternal health determinants of placental transfer of organochlorine compounds
AU - Patayová, Henrieta
AU - Wimmerová, Soňa
AU - Lancz, Kinga
AU - Palkovičová, Ľubica
AU - Drobná, Beata
AU - Fabišiková, Anna
AU - Kováč, Ján
AU - Hertz-Picciotto, Irva
AU - Jusko, Todd A.
AU - Trnovec, Tomáš
PY - 2013
Y1 - 2013
N2 - The aim of this study was to relate placental transfer, quantified by the cord to maternal serum concentration ratio (C/M), of five organochlorine pesticides (OCP) hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), γ-hexachlorocyclohexane (γ-HCH), p,p'-DDT, p,p'-DDE and 15 polychlorinated biphenyl (PCB) congeners (28, 52, 101, 105, 114, 118, 123+149, 138+163, 153, 156+171, 157, 167, 170, 180, and 189) to anthropometric, socioeconomic, and maternal health characteristics. We included into the study 1,134 births during the period 2002-2004 from two districts in eastern Slovakia with high organochlorine concentrations relative to other areas of the world. Only concentrations >LOD were taken into account. Variables as age, weight and height of mothers, parity, ethnicity, alcohol consumption, illness during pregnancy, smoking during pregnancy, hypertension, respiratory diseases, rheumatoid arthritis and diabetes mellitus, and birth weight were related to C/M. Results of regression analyses showed that C/M was predicted by several factors studied. Positive associations were observed for gestational alcohol consumption, fewer illnesses during pregnancy, maternal age, and maternal weight. Caucasians had a greater C/M compared to Romani for wet weight data of congeners 170 and 180 and in contrast C/M for HCB was greater in Romani. Our results show that drinking mothers compared to abstaining expose their fetuses not only to alcohol but to an increased level of several PCB congeners. A straightforward explanation of associations between C/M shifts and factors studied is very difficult, however, with regard to the high lipophilicity of OCPs and PCBs, changes in their kinetics probably reflect lipid kinetics.
AB - The aim of this study was to relate placental transfer, quantified by the cord to maternal serum concentration ratio (C/M), of five organochlorine pesticides (OCP) hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), γ-hexachlorocyclohexane (γ-HCH), p,p'-DDT, p,p'-DDE and 15 polychlorinated biphenyl (PCB) congeners (28, 52, 101, 105, 114, 118, 123+149, 138+163, 153, 156+171, 157, 167, 170, 180, and 189) to anthropometric, socioeconomic, and maternal health characteristics. We included into the study 1,134 births during the period 2002-2004 from two districts in eastern Slovakia with high organochlorine concentrations relative to other areas of the world. Only concentrations >LOD were taken into account. Variables as age, weight and height of mothers, parity, ethnicity, alcohol consumption, illness during pregnancy, smoking during pregnancy, hypertension, respiratory diseases, rheumatoid arthritis and diabetes mellitus, and birth weight were related to C/M. Results of regression analyses showed that C/M was predicted by several factors studied. Positive associations were observed for gestational alcohol consumption, fewer illnesses during pregnancy, maternal age, and maternal weight. Caucasians had a greater C/M compared to Romani for wet weight data of congeners 170 and 180 and in contrast C/M for HCB was greater in Romani. Our results show that drinking mothers compared to abstaining expose their fetuses not only to alcohol but to an increased level of several PCB congeners. A straightforward explanation of associations between C/M shifts and factors studied is very difficult, however, with regard to the high lipophilicity of OCPs and PCBs, changes in their kinetics probably reflect lipid kinetics.
KW - Alcohol
KW - Organochlorine pesticides
KW - PCB
KW - Placental transfer
UR - http://www.scopus.com/inward/record.url?scp=84891164763&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891164763&partnerID=8YFLogxK
U2 - 10.1007/s11356-013-1786-7
DO - 10.1007/s11356-013-1786-7
M3 - Article
C2 - 23677752
AN - SCOPUS:84891164763
VL - 20
SP - 8557
EP - 8566
JO - Environmental Science and Pollution Research
JF - Environmental Science and Pollution Research
SN - 0944-1344
IS - 12
ER -