Anterior cingulate cortex activity and impaired self-monitoring of performance in patients with schizophrenia: An event-related fMRI study

Cameron S Carter, A. W. MacDonald, L. L. Ross, V. A. Stenger

Research output: Contribution to journalArticle

310 Citations (Scopus)

Abstract

Objective: The authors examined brain activity associated with the internal monitoring of performance to test the hypothesis that error-related activity in the anterior cingulate cortex is impaired in patients with schizophrenia. Method: Seventeen patients with schizophrenia and 16 healthy comparison subjects underwent event-related functional magnetic resonance imaging during a continuous performance task; stimulus degradation was used to increase error rates. Results: Comparison subjects, but not schizophrenic patients, showed error-related activity in the anterior cingulate cortex, and this difference in brain activity was significantly different across the two groups. Patients also showed less slowing of reaction time after error commission. Conclusions: Lower error-related activity in the anterior cingulate cortex and less performance adjustment after error commission are consistent with the hypothesis that disturbances in anterior cingulate cortex function are related to a specific alteration in an evaluative component of executive functioning - the internal monitoring of performance.

Original languageEnglish (US)
Pages (from-to)1423-1428
Number of pages6
JournalAmerican Journal of Psychiatry
Volume158
Issue number9
DOIs
StatePublished - 2001
Externally publishedYes

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Gyrus Cinguli
Schizophrenia
Magnetic Resonance Imaging
Social Adjustment
Brain
Task Performance and Analysis
Reaction Time
Healthy Volunteers

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Anterior cingulate cortex activity and impaired self-monitoring of performance in patients with schizophrenia : An event-related fMRI study. / Carter, Cameron S; MacDonald, A. W.; Ross, L. L.; Stenger, V. A.

In: American Journal of Psychiatry, Vol. 158, No. 9, 2001, p. 1423-1428.

Research output: Contribution to journalArticle

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