Antagonism of xylazine induced sedation by idazoxan in calves.

T. J. Doherty, J. A. Ballinger, W. N. McDonell, Peter J Pascoe, A. E. Valliant

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Idazoxan was studied at three dose rates to assess its potential as an antagonist to xylazine. Calves in the study group were initially given xylazine at a dose rate of 0.2 mg/kg intravenously followed 12 minutes later by idazoxan at a dose rate of either 0.05, 0.075 or 0.10 mg/kg intravenously. A control group received a saline injection instead of idazoxan. All three dose levels of idazoxan successfully reversed the xylazine induced central nervous depression and all animals stood within two minutes of injection. No residual signs of sedation were noticed and relapse did not occur. In addition idazoxan was successful in reversing respiratory and cardiovascular depression produced by xylazine. The results indicated that idazoxan may be used for rapid reversal of xylazine induced sedation in calves.

Original languageEnglish (US)
Pages (from-to)244-248
Number of pages5
JournalCanadian journal of veterinary research = Revue canadienne de recherche veterinaire
Issue number2
StatePublished - Apr 1987
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)


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