Antagonism of the anxiolytic action of diazepam and chlordiazepoxide by the novel imidazopyridines, EMD 39593 and EMD 41717

Phil Skolnick, Steven Paul, Jacqueline Crawley, Edward Lewin, Arnold Lippa, Donald Clody, Klaus Irmscher, Otto Saiko, Klaus Otto Minck

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The imidazopyridines EMD 35993 and EMD 41717 antagonized the anticonflict actions of diazepam and chlordiazepoxide in rodent models which are predictive for anxiolytic action in man. In contrast to other described benzodiazepine antagonists, these compounds did not antagonize either the anticonvulsant or muscle relaxant properties of either benzodiazepine. Both EMD 39593 and EMD 41717 competitively inhibit the binding of [3H]diazepam to brain membranes, but do not exhibit regional differences in potency. These observations suggest that both EMD 39593 and EMD 41717 display some selectivity in antagonizing the anxiolytic properties of benzodiazepines, and as such may be useful tools in identifying neuronal substrates of anxiety.

Original languageEnglish (US)
Pages (from-to)319-327
Number of pages9
JournalEuropean Journal of Pharmacology
Volume88
Issue number4
DOIs
StatePublished - Apr 8 1983
Externally publishedYes

Keywords

  • Benzodiazepine antagonists
  • EMD 39593
  • EMD 41717
  • Imidazopyridines

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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