Abstract
Anomalous rectification occurred in 54 of 56 hippocampal CA1 neurons studied in vitro. This phenomenon is characterized by a progressive increase in input resistance with membrane depolarization. An average increase in membrane resistance of 45% occurred over a 15-mV region of membrane potential immediately subthreshold to cellular firing. Both Mn2+, a Ca+ antagonist, and tetrodotoxin (TTX), a neurotoxin that blocks regenerative Na+ currents, eliminated anomalous rectification. Ba2+, which can both contribute to intracellular cation influx as well as reduce K+ conductance, increased the magnitude of anomalous rectification. These observations are indirect evidence indicating that a Ca2+-Na+ current may produce the inward-going rectification. Enhancement of anomalous rectification by Ba2+ was associated with the onset of membrane oscillations and spontaneous bursts of repetitive discharges. The magnitude of anomalous rectification may be one factor that predisposes some cortical neurons to bursting behavior.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 889-895 |
| Number of pages | 7 |
| Journal | Journal of Neurophysiology |
| Volume | 42 |
| Issue number | 3 |
| State | Published - 1979 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Physiology
- Neuroscience(all)
Cite this
Anomalous inward rectification in hippocampal neurons. / Hotson, J. R.; Prince, D. A.; Schwartzkroin, Philip A.
In: Journal of Neurophysiology, Vol. 42, No. 3, 1979, p. 889-895.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anomalous inward rectification in hippocampal neurons
AU - Hotson, J. R.
AU - Prince, D. A.
AU - Schwartzkroin, Philip A
PY - 1979
Y1 - 1979
N2 - Anomalous rectification occurred in 54 of 56 hippocampal CA1 neurons studied in vitro. This phenomenon is characterized by a progressive increase in input resistance with membrane depolarization. An average increase in membrane resistance of 45% occurred over a 15-mV region of membrane potential immediately subthreshold to cellular firing. Both Mn2+, a Ca+ antagonist, and tetrodotoxin (TTX), a neurotoxin that blocks regenerative Na+ currents, eliminated anomalous rectification. Ba2+, which can both contribute to intracellular cation influx as well as reduce K+ conductance, increased the magnitude of anomalous rectification. These observations are indirect evidence indicating that a Ca2+-Na+ current may produce the inward-going rectification. Enhancement of anomalous rectification by Ba2+ was associated with the onset of membrane oscillations and spontaneous bursts of repetitive discharges. The magnitude of anomalous rectification may be one factor that predisposes some cortical neurons to bursting behavior.
AB - Anomalous rectification occurred in 54 of 56 hippocampal CA1 neurons studied in vitro. This phenomenon is characterized by a progressive increase in input resistance with membrane depolarization. An average increase in membrane resistance of 45% occurred over a 15-mV region of membrane potential immediately subthreshold to cellular firing. Both Mn2+, a Ca+ antagonist, and tetrodotoxin (TTX), a neurotoxin that blocks regenerative Na+ currents, eliminated anomalous rectification. Ba2+, which can both contribute to intracellular cation influx as well as reduce K+ conductance, increased the magnitude of anomalous rectification. These observations are indirect evidence indicating that a Ca2+-Na+ current may produce the inward-going rectification. Enhancement of anomalous rectification by Ba2+ was associated with the onset of membrane oscillations and spontaneous bursts of repetitive discharges. The magnitude of anomalous rectification may be one factor that predisposes some cortical neurons to bursting behavior.
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M3 - Article
C2 - 430121
AN - SCOPUS:0018394722
VL - 42
SP - 889
EP - 895
JO - Journal of Neurophysiology
JF - Journal of Neurophysiology
SN - 0022-3077
IS - 3
ER -