Anomalies beyond sites of chromatic opponency contribute to sensitivity losses of an S-cone pathway in diabetes

B. E. Schefrin, A. J. Adams, John S Werner

Research output: Contribution to journalArticle

12 Scopus citations


Threshold vs radiance (tvr) functions and the loci of spectral unique blue and unique green were measured for six diabetic subjects and four age-matched controls. The tvr functions provided an indication of cone-sensitivity losses of diabetics compared to controls, while the unique hue loci were used to assess relative cone contributions to chromatic-opponent pathways. If the sensitivity losses of S-cone pathways observed in diabetic subjects were due only to anomalies before the sites of chromatic opponency, current models of chromatic pathways would predict that unique blue and unique green should be shifted towards shorter wavelengths relative to control subjects. With one exception, the unique hue loci for all tested diabetic subjects, including those with relatively large sensitivity losses of their short-wavelength-sensitivity (S-) cone pathways, fell within the range of unique hue loci for the controls. The results are consistent with the hypothesis that diabetes produces a defect beyond the sites that encode the sensations of unique blue and unique green within chromatically-opponent pathways.

Original languageEnglish (US)
Pages (from-to)219-228
Number of pages10
JournalClinical Vision Sciences
Issue number3
StatePublished - 1991
Externally publishedYes


ASJC Scopus subject areas

  • Ophthalmology

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