Annotation: The neural basis of social impairments in autism: The role of the dorsal medial-frontal cortex and anterior cingulate system

Research output: Contribution to journalArticle

252 Citations (Scopus)

Abstract

Background: The fundamental social disturbance of autism is characterized, in part, by problems in the acquisition of joint attention skills in the first years of life, followed by impairments in the development of social cognition, as assessed on theory of mind (ToM) measures. Recently, studies have indicated that a system involving the dorsal medial-frontal cortex (DMFC), and the anterior cingulate (AC), may contribute to the development of the tendency to initiate joint attention in infancy. Similarly, research has implicated the DMFC/AC system in ToM performance in typical and atypical individuals. These data suggest it may be useful to consider the functions associated with this system in the developmental psychopathology of autism. Method: A review of the studies of the connections between the DMFC/AC system, joint attention and ToM task performance. Results and conclusions: This review raises the hypothesis that the DMFC/AC may be involved in the basic disturbance in social orienting in autism. The DMFAC/AC may also play a role in the capacity to monitor proprioceptive information concerning self-action and integrate this self-related information with exteroceptive perceptual information about the behavior of other people. A disturbance in these functions of the DMFC/AC may contribute to the atypical development of intersubjectivity, joint attention and social cognition that may impair the lives of people with autism. Thus, impairment in the development of this system may constitute a neural substrate for socio-cognitive deficits in autism.

Original languageEnglish (US)
Pages (from-to)793-809
Number of pages17
JournalJournal of Child Psychology and Psychiatry and Allied Disciplines
Volume44
Issue number6
DOIs
StatePublished - Sep 2003
Externally publishedYes

Fingerprint

Gyrus Cinguli
Frontal Lobe
Autistic Disorder
Theory of Mind
Cognition
Task Performance and Analysis
Psychopathology
Research

Keywords

  • Anterior cingulate
  • Autism
  • Brain imaging
  • Frontal cortex
  • Joint attention
  • Social cognition
  • Social orienting

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology

Cite this

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abstract = "Background: The fundamental social disturbance of autism is characterized, in part, by problems in the acquisition of joint attention skills in the first years of life, followed by impairments in the development of social cognition, as assessed on theory of mind (ToM) measures. Recently, studies have indicated that a system involving the dorsal medial-frontal cortex (DMFC), and the anterior cingulate (AC), may contribute to the development of the tendency to initiate joint attention in infancy. Similarly, research has implicated the DMFC/AC system in ToM performance in typical and atypical individuals. These data suggest it may be useful to consider the functions associated with this system in the developmental psychopathology of autism. Method: A review of the studies of the connections between the DMFC/AC system, joint attention and ToM task performance. Results and conclusions: This review raises the hypothesis that the DMFC/AC may be involved in the basic disturbance in social orienting in autism. The DMFAC/AC may also play a role in the capacity to monitor proprioceptive information concerning self-action and integrate this self-related information with exteroceptive perceptual information about the behavior of other people. A disturbance in these functions of the DMFC/AC may contribute to the atypical development of intersubjectivity, joint attention and social cognition that may impair the lives of people with autism. Thus, impairment in the development of this system may constitute a neural substrate for socio-cognitive deficits in autism.",
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