Abstract
Objectives: In recent years, great progress has been made in the development of diagnostic tools, therapeutic approaches, and validated outcome measures in the understanding of the pathogenesis of ankylosing spondylitis (AS). The purpose of this review was to summarize these developments. Methods: We performed a PubMed search for the period 1978 to 2005, using the keyword, "ankylosing spondylitis," resulting in a total of 4878 publications, including 778 reviews. Articles were then selected based on their discussion of recent diagnostic tools and new treatment approaches in the pathogenesis of AS, leading to a final total of 104 articles. Results: In recent years, there have been 2 major developments in the management of AS that make earlier diagnosis possible and offer the hope of alleviating pain and preventing structural changes that result in loss of function. These developments include the use of magnetic resonance imaging to visualize the inflammatory changes in the sacroiliac joint and the axial spine, and the demonstration that tumor necrosis factor blocking agents are highly efficacious in reducing spinal inflammation and possibly in slowing radiographic progression. Conclusions: There have been major advances in both the diagnostic tools and the therapeutic regimens available for patients with AS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 210-223 |
| Number of pages | 14 |
| Journal | Seminars in Arthritis and Rheumatism |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| State | Published - Feb 2007 |
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Keywords
- computed tomography
- sacroiliitis, HLA B27
- seronegative spondyloarthritis
- TNF blocking agents
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
- Orthopedics and Sports Medicine
- Rheumatology
Cite this
Ankylosing Spondylitis : A Contemporary Perspective on Diagnosis and Treatment. / Mansour, Mark; Cheema, Gurtej S.; Naguwa, Stanley M; Greenspan, Adam; Borchers, Andrea T.; Keen, Carl L; Gershwin, M. Eric.
In: Seminars in Arthritis and Rheumatism, Vol. 36, No. 4, 02.2007, p. 210-223.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ankylosing Spondylitis
T2 - A Contemporary Perspective on Diagnosis and Treatment
AU - Mansour, Mark
AU - Cheema, Gurtej S.
AU - Naguwa, Stanley M
AU - Greenspan, Adam
AU - Borchers, Andrea T.
AU - Keen, Carl L
AU - Gershwin, M. Eric
PY - 2007/2
Y1 - 2007/2
N2 - Objectives: In recent years, great progress has been made in the development of diagnostic tools, therapeutic approaches, and validated outcome measures in the understanding of the pathogenesis of ankylosing spondylitis (AS). The purpose of this review was to summarize these developments. Methods: We performed a PubMed search for the period 1978 to 2005, using the keyword, "ankylosing spondylitis," resulting in a total of 4878 publications, including 778 reviews. Articles were then selected based on their discussion of recent diagnostic tools and new treatment approaches in the pathogenesis of AS, leading to a final total of 104 articles. Results: In recent years, there have been 2 major developments in the management of AS that make earlier diagnosis possible and offer the hope of alleviating pain and preventing structural changes that result in loss of function. These developments include the use of magnetic resonance imaging to visualize the inflammatory changes in the sacroiliac joint and the axial spine, and the demonstration that tumor necrosis factor blocking agents are highly efficacious in reducing spinal inflammation and possibly in slowing radiographic progression. Conclusions: There have been major advances in both the diagnostic tools and the therapeutic regimens available for patients with AS.
AB - Objectives: In recent years, great progress has been made in the development of diagnostic tools, therapeutic approaches, and validated outcome measures in the understanding of the pathogenesis of ankylosing spondylitis (AS). The purpose of this review was to summarize these developments. Methods: We performed a PubMed search for the period 1978 to 2005, using the keyword, "ankylosing spondylitis," resulting in a total of 4878 publications, including 778 reviews. Articles were then selected based on their discussion of recent diagnostic tools and new treatment approaches in the pathogenesis of AS, leading to a final total of 104 articles. Results: In recent years, there have been 2 major developments in the management of AS that make earlier diagnosis possible and offer the hope of alleviating pain and preventing structural changes that result in loss of function. These developments include the use of magnetic resonance imaging to visualize the inflammatory changes in the sacroiliac joint and the axial spine, and the demonstration that tumor necrosis factor blocking agents are highly efficacious in reducing spinal inflammation and possibly in slowing radiographic progression. Conclusions: There have been major advances in both the diagnostic tools and the therapeutic regimens available for patients with AS.
KW - computed tomography
KW - sacroiliitis, HLA B27
KW - seronegative spondyloarthritis
KW - TNF blocking agents
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UR - http://www.scopus.com/inward/citedby.url?scp=33846647017&partnerID=8YFLogxK
U2 - 10.1016/j.semarthrit.2006.08.003
DO - 10.1016/j.semarthrit.2006.08.003
M3 - Article
VL - 36
SP - 210
EP - 223
JO - Seminars in Arthritis and Rheumatism
JF - Seminars in Arthritis and Rheumatism
SN - 0049-0172
IS - 4
ER -