Abstract
We have measured the fluxes of 82Br or 131I across short-circuited dog tracheal epithelium following complete replacement of chloride in the bathing medium by either bromide or iodide. In addition, we have partly replaced the bathing chloride with bromide, iodide, or thiocyanate and studied the effects of these anions on 36Cl fluxes. Our results show that the affinity sequence for the chloride transport process is I > Br congruent to Cl, that Br is transported, but that I is not. Thiocyanate is a potent inhibitor of chloride transport, and its effects are greater than those predicted by a simple competitive interaction with chloride for transport sites.
| Original language | English (US) |
|---|---|
| Journal | The American journal of physiology |
| Volume | 239 |
| Issue number | 3 |
| State | Published - Sep 1980 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Anion selectivity of the chloride-transport process in dog tracheal epithelium. / Widdicombe, J. H.; Welsh, M. J.
In: The American journal of physiology, Vol. 239, No. 3, 09.1980.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anion selectivity of the chloride-transport process in dog tracheal epithelium.
AU - Widdicombe, J. H.
AU - Welsh, M. J.
PY - 1980/9
Y1 - 1980/9
N2 - We have measured the fluxes of 82Br or 131I across short-circuited dog tracheal epithelium following complete replacement of chloride in the bathing medium by either bromide or iodide. In addition, we have partly replaced the bathing chloride with bromide, iodide, or thiocyanate and studied the effects of these anions on 36Cl fluxes. Our results show that the affinity sequence for the chloride transport process is I > Br congruent to Cl, that Br is transported, but that I is not. Thiocyanate is a potent inhibitor of chloride transport, and its effects are greater than those predicted by a simple competitive interaction with chloride for transport sites.
AB - We have measured the fluxes of 82Br or 131I across short-circuited dog tracheal epithelium following complete replacement of chloride in the bathing medium by either bromide or iodide. In addition, we have partly replaced the bathing chloride with bromide, iodide, or thiocyanate and studied the effects of these anions on 36Cl fluxes. Our results show that the affinity sequence for the chloride transport process is I > Br congruent to Cl, that Br is transported, but that I is not. Thiocyanate is a potent inhibitor of chloride transport, and its effects are greater than those predicted by a simple competitive interaction with chloride for transport sites.
UR - http://www.scopus.com/inward/record.url?scp=0019064701&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019064701&partnerID=8YFLogxK
M3 - Article
C2 - 7435549
AN - SCOPUS:0019064701
VL - 239
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
SN - 1931-857X
IS - 3
ER -