Animal models to study the pathogenesis of enterotoxigenic Clostridium perfringens infections

Francisco A Uzal, Bruce A. McClane

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Rabbits, mice, rats, non-human primates, sheep and cattle have been used to study the effect of Clostridium perfringens enterotoxin (CPE). CPE produces mostly necrosis of the small intestinal epithelium along with fluid accumulation in rabbits and mice. In the latter, CPE can bind to internal organs such as the liver, which induces lethal potassium levels in blood.

Original languageEnglish (US)
Pages (from-to)1009-1016
Number of pages8
JournalMicrobes and Infection
Volume14
Issue number12
DOIs
StatePublished - Oct 2012

Keywords

  • Animal models
  • Clostridium perfringens
  • Enterotoxin

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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