Animal models of disease: classification and etiology of diabetes in dogs and cats.

Richard W Nelson, Claudia E. Reusch

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Diabetes mellitus is a common disease in dogs and cats. The most common form of diabetes in dogs resembles type 1 diabetes in humans. Studies suggest that genetics, an immune-mediated component, and environmental factors are involved in the development of diabetes in dogs. A variant of gestational diabetes also occurs in dogs. The most common form of diabetes in cats resembles type 2 diabetes in humans. A major risk factor in cats is obesity. Obese cats have altered expression of several insulin signaling genes and glucose transporters and are leptin resistant. Cats also form amyloid deposits within the islets of the pancreas and develop glucotoxicity when exposed to prolonged hyperglycemia. This review will briefly summarize our current knowledge about the etiology of diabetes in dogs and cats and illustrate the similarities among dogs, cats, and humans.

Original languageEnglish (US)
JournalThe Journal of endocrinology
Volume222
Issue number3
DOIs
StatePublished - 2014

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Animal Disease Models
Cats
Dogs
Cat Diseases
Dog Diseases
Gestational Diabetes
Facilitative Glucose Transport Proteins
Amyloid Plaques
Leptin
Type 1 Diabetes Mellitus
Hyperglycemia
Type 2 Diabetes Mellitus
Pancreas
Diabetes Mellitus
Obesity
Insulin
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Animal models of disease : classification and etiology of diabetes in dogs and cats. / Nelson, Richard W; Reusch, Claudia E.

In: The Journal of endocrinology, Vol. 222, No. 3, 2014.

Research output: Contribution to journalArticle

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