Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation

Michael Dale Lairmore, Lee Silverman, Lee Ratner

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Over the past 25 years, animal models of human T-lymphotropic virus type 1 (HTLV-1) infection and transformation have provided critical knowledge about viral and host factors in adult T-cell leukemia/lymphoma (ATL). The virus consistently infects rabbits, some non-human primates, and to a lesser extent rats. In addition to providing fundamental concepts in viral transmission and immune responses against HTLV-1 infection, these models have provided new information about the role of viral proteins in carcinogenesis. Mice and rats, in particular immunodeficient strains, are useful models to assess immunologic parameters mediating tumor outgrowth and therapeutic invention strategies against lymphoma. Genetically altered mice including both transgenic and knockout mice offer important models to test the role of specific viral and host genes in the development of HTLV-1-associated lymphoma. Novel approaches in genetic manipulation of both HTLV-1 and animal models are available to address the complex questions that remain about viral-mediated mechanisms of cell transformation and disease. Current progress in the understanding of the molecular events of HTLV-1 infection and transformation suggests that answers to these questions are approachable using animal models of HTLV-1-associated lymphoma.

Original languageEnglish (US)
Pages (from-to)6005-6015
Number of pages11
JournalOncogene
Volume24
Issue number39
DOIs
StatePublished - Sep 5 2005
Externally publishedYes

Keywords

  • Animal models
  • HTLV-1
  • Leukemia
  • Lymphoma

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Fingerprint Dive into the research topics of 'Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation'. Together they form a unique fingerprint.

  • Cite this