Abstract
Because of the ready availability of nude mice, it is becoming increasingly apparent that such animals can be manipulated and serve as testing grounds for induction of T-cell maturation, regulation of the immune response, and elucidation of cytotoxic responses in allografts. Moreover, they permit definitive characterization of the degree of thymic dependency as a primary defense against infectious agents. Extrapolation of data from mouse to man must be done with considerable caution. However, the nude mouse represents one of the most versatile tools in immunobiology and should continue to facilitate our understanding and assessment of the role of the thymus in infection, transplantation, autoimmunity, oncology and gerontology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 809-812 |
| Number of pages | 4 |
| Journal | American Journal of Pathology |
| Volume | 89 |
| Issue number | 3 |
| State | Published - 1977 |
Fingerprint
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Animal model of human disease. DiGeorge syndrome : Congenital thymic hypoplasia. / Gershwin, M. Eric.
In: American Journal of Pathology, Vol. 89, No. 3, 1977, p. 809-812.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Animal model of human disease. DiGeorge syndrome
T2 - Congenital thymic hypoplasia
AU - Gershwin, M. Eric
PY - 1977
Y1 - 1977
N2 - Because of the ready availability of nude mice, it is becoming increasingly apparent that such animals can be manipulated and serve as testing grounds for induction of T-cell maturation, regulation of the immune response, and elucidation of cytotoxic responses in allografts. Moreover, they permit definitive characterization of the degree of thymic dependency as a primary defense against infectious agents. Extrapolation of data from mouse to man must be done with considerable caution. However, the nude mouse represents one of the most versatile tools in immunobiology and should continue to facilitate our understanding and assessment of the role of the thymus in infection, transplantation, autoimmunity, oncology and gerontology.
AB - Because of the ready availability of nude mice, it is becoming increasingly apparent that such animals can be manipulated and serve as testing grounds for induction of T-cell maturation, regulation of the immune response, and elucidation of cytotoxic responses in allografts. Moreover, they permit definitive characterization of the degree of thymic dependency as a primary defense against infectious agents. Extrapolation of data from mouse to man must be done with considerable caution. However, the nude mouse represents one of the most versatile tools in immunobiology and should continue to facilitate our understanding and assessment of the role of the thymus in infection, transplantation, autoimmunity, oncology and gerontology.
UR - http://www.scopus.com/inward/record.url?scp=0017733838&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017733838&partnerID=8YFLogxK
M3 - Article
C2 - 596425
AN - SCOPUS:0017733838
VL - 89
SP - 809
EP - 812
JO - American Journal of Pathology
JF - American Journal of Pathology
SN - 0002-9440
IS - 3
ER -