Abstract
We report a case of cutaneous postradiation angiosarcoma of the breast exhibiting pseudoepidermotropism that resembled metastatic adenocarcinoma on hematoxylin and eosin. The patient is a 74-year-old woman with history of breast carcinoma treated with mastectomy, chemotherapy, and radiotherapy who complained of an erythematous "rash" along the central portion of the mastectomy scar. Radiography showed widespread osseous metastasis. Biopsy revealed an infiltrative tumor with single file growth and tumor cells obscuring the dermal-epidermal junction in multiple foci, imparting an appearance of epidermotropism. The tumor cells were positive for CD31, CD34, and D2-40 and negative for Cam 5.2. This novel case of pseudoepidermotropic angiosarcoma highlights a potential pitfall in the histomorphologic assessment of poorly differentiated angiosarcoma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 400-402 |
| Number of pages | 3 |
| Journal | American Journal of Dermatopathology |
| Volume | 33 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jun 2011 |
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Keywords
- breast carcinoma
- epidermotropic metastasis
- epidermotropism
- postradiation angiosarcoma
- pseudoepidermotropism
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Dermatology
Cite this
Angiosarcoma with pseudoepidermotropism in a patient with breast cancer : A mimic of epidermotropic metastatic adenocarcinoma. / Liu, Yen Chen; Fung, Maxwell A.
In: American Journal of Dermatopathology, Vol. 33, No. 4, 06.2011, p. 400-402.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Angiosarcoma with pseudoepidermotropism in a patient with breast cancer
T2 - A mimic of epidermotropic metastatic adenocarcinoma
AU - Liu, Yen Chen
AU - Fung, Maxwell A
PY - 2011/6
Y1 - 2011/6
N2 - We report a case of cutaneous postradiation angiosarcoma of the breast exhibiting pseudoepidermotropism that resembled metastatic adenocarcinoma on hematoxylin and eosin. The patient is a 74-year-old woman with history of breast carcinoma treated with mastectomy, chemotherapy, and radiotherapy who complained of an erythematous "rash" along the central portion of the mastectomy scar. Radiography showed widespread osseous metastasis. Biopsy revealed an infiltrative tumor with single file growth and tumor cells obscuring the dermal-epidermal junction in multiple foci, imparting an appearance of epidermotropism. The tumor cells were positive for CD31, CD34, and D2-40 and negative for Cam 5.2. This novel case of pseudoepidermotropic angiosarcoma highlights a potential pitfall in the histomorphologic assessment of poorly differentiated angiosarcoma.
AB - We report a case of cutaneous postradiation angiosarcoma of the breast exhibiting pseudoepidermotropism that resembled metastatic adenocarcinoma on hematoxylin and eosin. The patient is a 74-year-old woman with history of breast carcinoma treated with mastectomy, chemotherapy, and radiotherapy who complained of an erythematous "rash" along the central portion of the mastectomy scar. Radiography showed widespread osseous metastasis. Biopsy revealed an infiltrative tumor with single file growth and tumor cells obscuring the dermal-epidermal junction in multiple foci, imparting an appearance of epidermotropism. The tumor cells were positive for CD31, CD34, and D2-40 and negative for Cam 5.2. This novel case of pseudoepidermotropic angiosarcoma highlights a potential pitfall in the histomorphologic assessment of poorly differentiated angiosarcoma.
KW - breast carcinoma
KW - epidermotropic metastasis
KW - epidermotropism
KW - postradiation angiosarcoma
KW - pseudoepidermotropism
UR - http://www.scopus.com/inward/record.url?scp=79958252588&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958252588&partnerID=8YFLogxK
U2 - 10.1097/DAD.0b013e3181e7a2d3
DO - 10.1097/DAD.0b013e3181e7a2d3
M3 - Article
C2 - 21124204
AN - SCOPUS:79958252588
VL - 33
SP - 400
EP - 402
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
SN - 0193-1091
IS - 4
ER -