Angiosarcoma with pseudoepidermotropism in a patient with breast cancer: A mimic of epidermotropic metastatic adenocarcinoma

Yen Chen Liu, Maxwell A Fung

Research output: Contribution to journalArticle

1 Scopus citations


We report a case of cutaneous postradiation angiosarcoma of the breast exhibiting pseudoepidermotropism that resembled metastatic adenocarcinoma on hematoxylin and eosin. The patient is a 74-year-old woman with history of breast carcinoma treated with mastectomy, chemotherapy, and radiotherapy who complained of an erythematous "rash" along the central portion of the mastectomy scar. Radiography showed widespread osseous metastasis. Biopsy revealed an infiltrative tumor with single file growth and tumor cells obscuring the dermal-epidermal junction in multiple foci, imparting an appearance of epidermotropism. The tumor cells were positive for CD31, CD34, and D2-40 and negative for Cam 5.2. This novel case of pseudoepidermotropic angiosarcoma highlights a potential pitfall in the histomorphologic assessment of poorly differentiated angiosarcoma.

Original languageEnglish (US)
Pages (from-to)400-402
Number of pages3
JournalAmerican Journal of Dermatopathology
Issue number4
StatePublished - Jun 2011



  • breast carcinoma
  • epidermotropic metastasis
  • epidermotropism
  • postradiation angiosarcoma
  • pseudoepidermotropism

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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