Angiosarcoma with pseudoepidermotropism in a patient with breast cancer: A mimic of epidermotropic metastatic adenocarcinoma

Yen Chen Liu; Maxwell A Fung

doi:10.1097/DAD.0b013e3181e7a2d3

Angiosarcoma with pseudoepidermotropism in a patient with breast cancer: A mimic of epidermotropic metastatic adenocarcinoma

Yen Chen Liu, Maxwell A Fung

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We report a case of cutaneous postradiation angiosarcoma of the breast exhibiting pseudoepidermotropism that resembled metastatic adenocarcinoma on hematoxylin and eosin. The patient is a 74-year-old woman with history of breast carcinoma treated with mastectomy, chemotherapy, and radiotherapy who complained of an erythematous "rash" along the central portion of the mastectomy scar. Radiography showed widespread osseous metastasis. Biopsy revealed an infiltrative tumor with single file growth and tumor cells obscuring the dermal-epidermal junction in multiple foci, imparting an appearance of epidermotropism. The tumor cells were positive for CD31, CD34, and D2-40 and negative for Cam 5.2. This novel case of pseudoepidermotropic angiosarcoma highlights a potential pitfall in the histomorphologic assessment of poorly differentiated angiosarcoma.

Original language	English (US)
Pages (from-to)	400-402
Number of pages	3
Journal	American Journal of Dermatopathology
Volume	33
Issue number	4
DOIs	https://doi.org/10.1097/DAD.0b013e3181e7a2d3
State	Published - Jun 2011

Keywords

breast carcinoma
epidermotropic metastasis
epidermotropism
postradiation angiosarcoma
pseudoepidermotropism

ASJC Scopus subject areas

Pathology and Forensic Medicine
Dermatology

Access to Document

10.1097/DAD.0b013e3181e7a2d3

Cite this

@article{e296405681a84316b95ad4e4fb0818b6,

title = "Angiosarcoma with pseudoepidermotropism in a patient with breast cancer: A mimic of epidermotropic metastatic adenocarcinoma",

abstract = "We report a case of cutaneous postradiation angiosarcoma of the breast exhibiting pseudoepidermotropism that resembled metastatic adenocarcinoma on hematoxylin and eosin. The patient is a 74-year-old woman with history of breast carcinoma treated with mastectomy, chemotherapy, and radiotherapy who complained of an erythematous {"}rash{"} along the central portion of the mastectomy scar. Radiography showed widespread osseous metastasis. Biopsy revealed an infiltrative tumor with single file growth and tumor cells obscuring the dermal-epidermal junction in multiple foci, imparting an appearance of epidermotropism. The tumor cells were positive for CD31, CD34, and D2-40 and negative for Cam 5.2. This novel case of pseudoepidermotropic angiosarcoma highlights a potential pitfall in the histomorphologic assessment of poorly differentiated angiosarcoma.",

keywords = "breast carcinoma, epidermotropic metastasis, epidermotropism, postradiation angiosarcoma, pseudoepidermotropism",

author = "Liu, {Yen Chen} and Fung, {Maxwell A}",

year = "2011",

month = jun,

doi = "10.1097/DAD.0b013e3181e7a2d3",

language = "English (US)",

volume = "33",

pages = "400--402",

journal = "American Journal of Dermatopathology",

issn = "0193-1091",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

TY - JOUR

T1 - Angiosarcoma with pseudoepidermotropism in a patient with breast cancer

T2 - A mimic of epidermotropic metastatic adenocarcinoma

AU - Liu, Yen Chen

AU - Fung, Maxwell A

PY - 2011/6

Y1 - 2011/6

N2 - We report a case of cutaneous postradiation angiosarcoma of the breast exhibiting pseudoepidermotropism that resembled metastatic adenocarcinoma on hematoxylin and eosin. The patient is a 74-year-old woman with history of breast carcinoma treated with mastectomy, chemotherapy, and radiotherapy who complained of an erythematous "rash" along the central portion of the mastectomy scar. Radiography showed widespread osseous metastasis. Biopsy revealed an infiltrative tumor with single file growth and tumor cells obscuring the dermal-epidermal junction in multiple foci, imparting an appearance of epidermotropism. The tumor cells were positive for CD31, CD34, and D2-40 and negative for Cam 5.2. This novel case of pseudoepidermotropic angiosarcoma highlights a potential pitfall in the histomorphologic assessment of poorly differentiated angiosarcoma.

AB - We report a case of cutaneous postradiation angiosarcoma of the breast exhibiting pseudoepidermotropism that resembled metastatic adenocarcinoma on hematoxylin and eosin. The patient is a 74-year-old woman with history of breast carcinoma treated with mastectomy, chemotherapy, and radiotherapy who complained of an erythematous "rash" along the central portion of the mastectomy scar. Radiography showed widespread osseous metastasis. Biopsy revealed an infiltrative tumor with single file growth and tumor cells obscuring the dermal-epidermal junction in multiple foci, imparting an appearance of epidermotropism. The tumor cells were positive for CD31, CD34, and D2-40 and negative for Cam 5.2. This novel case of pseudoepidermotropic angiosarcoma highlights a potential pitfall in the histomorphologic assessment of poorly differentiated angiosarcoma.

KW - breast carcinoma

KW - epidermotropic metastasis

KW - epidermotropism

KW - postradiation angiosarcoma

KW - pseudoepidermotropism

UR - http://www.scopus.com/inward/record.url?scp=79958252588&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958252588&partnerID=8YFLogxK

U2 - 10.1097/DAD.0b013e3181e7a2d3

DO - 10.1097/DAD.0b013e3181e7a2d3

M3 - Article

C2 - 21124204

AN - SCOPUS:79958252588

VL - 33

SP - 400

EP - 402

JO - American Journal of Dermatopathology

JF - American Journal of Dermatopathology

SN - 0193-1091

IS - 4

ER -

Angiosarcoma with pseudoepidermotropism in a patient with breast cancer: A mimic of epidermotropic metastatic adenocarcinoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this