Angiogenesis induced by "normal" human breast tissue: A probable marker for precancer

Hanne M Jensen; Ibsen Chen; Martin R. Devault; Alvin E. Lewis

Angiogenesis induced by "normal" human breast tissue: A probable marker for precancer

Hanne M Jensen, Ibsen Chen, Martin R. Devault, Alvin E. Lewis

Pathology and Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

129 Scopus citations

Abstract

Normal human breast lobules, freshly isolated by precision microdissection of tissue stained with methylene blue chloride, were assayed for their ability to induce neovascularization (angiogenesis) in rabbit irises. Histologically, normal lobules from cancerous breasts induced angiogenesis twice as often as lobules from noncancerous breasts, suggesting that preneoplastic transformation is diffuse.

Original language	English (US)
Pages (from-to)	293-295
Number of pages	3
Journal	Science
Volume	218
Issue number	4569
State	Published - 1982

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abstract = "Normal human breast lobules, freshly isolated by precision microdissection of tissue stained with methylene blue chloride, were assayed for their ability to induce neovascularization (angiogenesis) in rabbit irises. Histologically, normal lobules from cancerous breasts induced angiogenesis twice as often as lobules from noncancerous breasts, suggesting that preneoplastic transformation is diffuse.",

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AB - Normal human breast lobules, freshly isolated by precision microdissection of tissue stained with methylene blue chloride, were assayed for their ability to induce neovascularization (angiogenesis) in rabbit irises. Histologically, normal lobules from cancerous breasts induced angiogenesis twice as often as lobules from noncancerous breasts, suggesting that preneoplastic transformation is diffuse.

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