Angiogenesis induced by "normal" human breast tissue: A probable marker for precancer

Hanne M Jensen, Ibsen Chen, Martin R. Devault, Alvin E. Lewis

Research output: Contribution to journalArticlepeer-review

129 Scopus citations

Abstract

Normal human breast lobules, freshly isolated by precision microdissection of tissue stained with methylene blue chloride, were assayed for their ability to induce neovascularization (angiogenesis) in rabbit irises. Histologically, normal lobules from cancerous breasts induced angiogenesis twice as often as lobules from noncancerous breasts, suggesting that preneoplastic transformation is diffuse.

Original languageEnglish (US)
Pages (from-to)293-295
Number of pages3
JournalScience
Volume218
Issue number4569
StatePublished - 1982

ASJC Scopus subject areas

  • General

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