Angiogenesis, the process of new vessel formation requires sequential activation of different growth factors and their cognate receptors. Angiogenesis and an inflammatory reaction are often parallel running processes. Contributing role of angiogenesis in the pathogenesis of various inflammatory diseases is well established. There are several possible mechanisms how angiogenesis influences inflammatory cascades of arthritic diseases. First, neovascularization increases the nutrient supply to tumor like synovium. Second, the expanded endothelial cell surface area in an inflamed joint maximizes the routes of ingress that allow immune and inflammatory cells to adhere and migrate into the synovium. Finally, activated endothelial cells provide a potent source of proinflammatory cytokines, chemokines, and growth factors. Among inflammatory diseases of rheumatologic origin, role of angiogenesis has been most extensively studied in rheumatoid arthritis. Currently there is a major focus to manipulate the regulatory mechanisms involved in neovascularization and endothelial cell activation. Drug development targeting the pathophysiologic processes of angiogenesis is a fast growing discipline in clinical pharmacology. In this chapter we have addressed the role of angiogenesis and its therapeutic implication in rheumatoid arthritis and other inflammatory arthritis.
|Original language||English (US)|
|Title of host publication||Anti-Angiogenic Functional and Medicinal Foods|
|Number of pages||33|
|ISBN (Print)||157444445X, 9781574444452|
|State||Published - Jan 1 2007|
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)