Angiogenesis and oxidative stress: Common mechanisms linking psoriasis with atherosclerosis

April W. Armstrong, Stephanie V. Voyles, Ehrin J. Armstrong, Erin N. Fuller, John C Rutledge

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

Shared angiogenic and oxidative mechanisms underlie the pathophysiology of psoriasis and atherosclerosis. During the pathogenesis of both diseases, stimuli such as injury or local hypoxia trigger the release of pro-angiogenic factors including IL-8, HIF-1α, ETS-1, and VEGF. These factors stimulate increased permeability and encourage leukocyte transmigration into areas of inflammation by enhanced expression of cell adhesion molecules. Psoriasis and atherosclerosis also share common enzymatic sources of reactive oxygen species (ROS), and these ROS influence several cellular signaling pathways implicated in the pathogenesis of both diseases. Pharmacologic and genetic therapies that target key factors in these pathways could provide innovative approaches to the management of psoriasis and potentially mitigate the cardiovascular complications suffered by psoriasis patients.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalJournal of Dermatological Science
Volume63
Issue number1
DOIs
StatePublished - Jul 2011

Keywords

  • Angiogenesis
  • Atherosclerosis
  • Oxidative stress
  • Psoriasis

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Molecular Biology

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