Anesthetic considerations in pediatric mastocytosis: A review

Norma J Klein, Shad Misseldine

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Mastocytosis is an orphan disease rarely encountered by practicing anesthesiologists. Children with mastocytosis often present for procedures or surgery requiring anesthesia. Because many of the medications commonly used in pediatric anesthesia have been reported to initiate mast cell activation, parents are often very anxious about their child's perioperative experience. Laboratory investigations of serum histamine assays associated with different anesthetic drugs have not been shown to predict mast cell degranulation in these patients. However, the pediatric literature suggests that children with disease limited to the skin rarely suffer serious side effects from anesthesia, and there are no reported fatalities. Preoperative prophylaxis is usually based on expert opinion and case reports. Detailed tables summarizing reports of anesthetic medications used for children with mastocytosis undergoing anesthesia, reported side effects, and suggested prophylaxis regimens are included in this review.

Original languageEnglish (US)
Pages (from-to)588-598
Number of pages11
JournalJournal of Anesthesia
Volume27
Issue number4
DOIs
StatePublished - Aug 2013

Fingerprint

Mastocytosis
Anesthetics
Anesthesia
Pediatrics
Mast Cells
Cell Degranulation
Expert Testimony
Rare Diseases
Histamine
Parents
Skin
Serum

Keywords

  • Anesthesia
  • Child
  • Mastocytosis/complications
  • Mastocytosis/therapy
  • Urticaria pigmentosa/therapy

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Anesthetic considerations in pediatric mastocytosis : A review. / Klein, Norma J; Misseldine, Shad.

In: Journal of Anesthesia, Vol. 27, No. 4, 08.2013, p. 588-598.

Research output: Contribution to journalArticle

Klein, Norma J ; Misseldine, Shad. / Anesthetic considerations in pediatric mastocytosis : A review. In: Journal of Anesthesia. 2013 ; Vol. 27, No. 4. pp. 588-598.
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