'Anesthesia paresthetica': Nitrous oxide-induced cobalamin deficiency

L. J. Kinsella, Ralph Green

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


A man with a subclinical cobalamin deficiency developed syncope, vertigo, paresthesias, and ataxia after two exposures to nitrous oxide anesthesia. Patients with unrecognized cobalamin deficiency may be particularly susceptible to brief exposures to nitrous oxide, which inactivates the cobalamin-dependent enzyme methionine synthase and may cause a myeloneuropathy. Clinicians should consider this entity when confronted with patients with neuropathic symptoms after surgical or dental procedures.

Original languageEnglish (US)
Pages (from-to)1608-1610
Number of pages3
Issue number8
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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