'Anesthesia paresthetica'

Nitrous oxide-induced cobalamin deficiency

L. J. Kinsella, Ralph Green

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

A man with a subclinical cobalamin deficiency developed syncope, vertigo, paresthesias, and ataxia after two exposures to nitrous oxide anesthesia. Patients with unrecognized cobalamin deficiency may be particularly susceptible to brief exposures to nitrous oxide, which inactivates the cobalamin-dependent enzyme methionine synthase and may cause a myeloneuropathy. Clinicians should consider this entity when confronted with patients with neuropathic symptoms after surgical or dental procedures.

Original languageEnglish (US)
Pages (from-to)1608-1610
Number of pages3
JournalNeurology
Volume45
Issue number8
StatePublished - 1995
Externally publishedYes

Fingerprint

Nitrous Oxide
Vitamin B 12
Anesthesia
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Paresthesia
Vertigo
Syncope
Ataxia
Tooth
Enzymes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

'Anesthesia paresthetica' : Nitrous oxide-induced cobalamin deficiency. / Kinsella, L. J.; Green, Ralph.

In: Neurology, Vol. 45, No. 8, 1995, p. 1608-1610.

Research output: Contribution to journalArticle

Kinsella, L. J. ; Green, Ralph. / 'Anesthesia paresthetica' : Nitrous oxide-induced cobalamin deficiency. In: Neurology. 1995 ; Vol. 45, No. 8. pp. 1608-1610.
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