Anemia, iron deficiency, and iron deficiency anemia in 12-36-mo-old children from low-income families

Julie M. Schneider, Mary L. Fujii, Catherine L. Lamp, Bo Lönnerdal, Kathryn G. Dewey, Sheri Zidenberg-Cherr

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58 Scopus citations

Abstract

Background: Iron deficiency (ID) is the most common nutritional deficiency in the world and remains relatively common in at-risk groups in the United States. The actual prevalence of anemia, ID, and iron deficiency anemia (IDA) in California remains unclear. Objective: The objective was to determine the prevalence of anemia, low iron stores, ID, and IDA in children participating in the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) population, and to assess the value of using hemoglobin to predict ID. Design: This was a cross-sectional study of a convenience sample of 12-36-mo-old children from WIC clinics in 2 California counties. Results: The prevalence of anemia was 11.1% (hemoglobin <110 g/L at 12-24 mo or <111 g/L at 24-36 mo). Study- and literature-determined abnormal values for iron measures were as follows: serum ferritin ≤8.7 or <10.0 μg/L, serum transferrin receptor ≥8.4 or >10.0 μg/mL, and transferrin saturation ≤13.2% or <10.0%, respectively. The prevalences of low iron stores (low ferritin) were 24.8% and 29.0%, of ID (≥2 abnormal iron measures) were 16.2% and 8.8%, and of IDA (ID with low hemoglobin) were 3.4% and 3.2% on the basis of study- and literature-determined cutoffs, respectively. Hemoglobin concentration was used to predict study- and literature-determined ID on the basis of receiver operating characteristic curves. The sensitivity of low hemoglobin in predicting study- and literature-determined ID was low (23.2% and 40.0%, respectively). Conclusions: Anemia and ID were prevalent in this WIC sample, but IDA was uncommon. Low hemoglobin is a poor predictor of ID.

Original languageEnglish (US)
Pages (from-to)1269-1275
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume82
Issue number6
StatePublished - 2005

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Keywords

  • Anemia
  • Iron deficiency
  • Serum ferritin
  • Serum transferrin receptors
  • Special Supplemental Nutrition Program for Women, Infants and Children
  • Toddlers
  • Transferrin saturation
  • WIC

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Schneider, J. M., Fujii, M. L., Lamp, C. L., Lönnerdal, B., Dewey, K. G., & Zidenberg-Cherr, S. (2005). Anemia, iron deficiency, and iron deficiency anemia in 12-36-mo-old children from low-income families. American Journal of Clinical Nutrition, 82(6), 1269-1275.