Androgens reduce HDL2-cholesterol and increase hepatic triglyceride lipase activity

Mark A. Kantor, Adam Bianchini, David Bernier, Stanley P. Sady, Paul D. Thompson

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

KANTOR, MARK A., ADAM BIANCHINI, DAVID BERNIER, STANLEY P. SADY, and PAUL D. THOMPSON. Androgens reduce HDL2-choIesterol and increase hepatic triglyceride lipase activity. Med. Sci. Sports Exerc., Vol. 17, No. 4, pp. 462-465, 1985. We quantified serum lipids and postheparin plasma lipolytic activities in 5 weightlifters presently self-administering androgenic steroids (users) and an equal number not currently using these drugs (nonusers). Mean (± SD) age (23 ± 2 vs 25 ± 4 yr), body weight (102.7 ± 11.4 vs 86.8 ± 13.6 kg), and percent body fat (8.6 ± 2.5 vs 7.8 ± 6.0%) were not different in users and non-users, respectively. Similarly, there were no differences in total cholesterol (183 ± 27 vs 176 ± 32 mg·dl-1) low-density lipoprotein-cholesterol (138 ± 25 vs 108 ± 32 mg·dl-1), or triglyceride (93 ± 26 vs 93 ± 41 mg·dl-1) levels in the two groups. High-density lipoprotein (HDL)-cholesterol concentrations, however, were significantly lower in the users (26 ± 10 vs 50 ± 13 mg·dl-10; P< 0.05), and most of the difference was due to lower HDL2-cholesterol concentrations (6 ± 4 vs 22 ± 9 mg·-dl-1; P<0.05). Postheparin plasma lipoprotein lipase activity was only slightly lower in the users (3.49 ± 2.23 vs 5.36 ± 1.73 μmol FFA·ml-h-1; P= NS), but hepatic triglyceride lipase activity was significantly higher in this group (27.99 ± 6.89 vs 11.15 ± 2.76, μmol FFA·mlhr-1: P<0.001) and correlated inversely with HDL2-cholesterol concentrations (r=-0.81; P<0.01). We conclude that androgenic hormones reduce HDL-cholesterol concentrations and the HDL2-cholcstcrol subfraction, possibly by enhancing hepatic triglyceride lipase activity.

Original languageEnglish (US)
Pages (from-to)462-465
Number of pages4
JournalMedicine and Science in Sports and Exercise
Volume17
Issue number4
StatePublished - 1985
Externally publishedYes

Keywords

  • Anabolic steroids
  • HDL-cholesterol
  • Lipase

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Public Health, Environmental and Occupational Health

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