Anchored reference loci for comparative genome mapping in mammals

Stephen J. O'brien, James E. Womack, Leslie A Lyons, Karen J. Moore, Nancy A. Jenkins, Neal G. Copeland

Research output: Contribution to journalArticle

433 Citations (Scopus)

Abstract

Recent advances in gene mapping technologies have led to increased emphasis in developing representative genetic maps for several species, particularly domestic plants and animals. These maps are being compiled with two distinct goals: to provide a resource for genetic analysis, and to help dissect the evolution of genome organization by comparing linkage relationships of homologous genes. We propose here a list of 321 reference anchor loci suitable for comparative gene mapping in mammals and other vertebrate classes. We selected cloned mouse and human functional genes spaced an average of 5-10 centiMorgans throughout their respective genomes. We also attempted to include loci that are evolutionary conserved and represented in comparative gene maps in other mammalian orders, particularly cattle and the domestic cat. We believe that the map may provide the basis for a unified approach to comparative analysis of mammalian species genomes.

Original languageEnglish (US)
Pages (from-to)103-112
Number of pages10
JournalNature Genetics
Volume3
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

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Chromosome Mapping
Mammals
Genome
Genes
Domestic Animals
Vertebrates
Cats
Technology

ASJC Scopus subject areas

  • Genetics

Cite this

O'brien, S. J., Womack, J. E., Lyons, L. A., Moore, K. J., Jenkins, N. A., & Copeland, N. G. (1993). Anchored reference loci for comparative genome mapping in mammals. Nature Genetics, 3(2), 103-112. https://doi.org/10.1038/ng0293-103

Anchored reference loci for comparative genome mapping in mammals. / O'brien, Stephen J.; Womack, James E.; Lyons, Leslie A; Moore, Karen J.; Jenkins, Nancy A.; Copeland, Neal G.

In: Nature Genetics, Vol. 3, No. 2, 1993, p. 103-112.

Research output: Contribution to journalArticle

O'brien, SJ, Womack, JE, Lyons, LA, Moore, KJ, Jenkins, NA & Copeland, NG 1993, 'Anchored reference loci for comparative genome mapping in mammals', Nature Genetics, vol. 3, no. 2, pp. 103-112. https://doi.org/10.1038/ng0293-103
O'brien, Stephen J. ; Womack, James E. ; Lyons, Leslie A ; Moore, Karen J. ; Jenkins, Nancy A. ; Copeland, Neal G. / Anchored reference loci for comparative genome mapping in mammals. In: Nature Genetics. 1993 ; Vol. 3, No. 2. pp. 103-112.
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