Anatomy of Herpes simplex virus DNA. XI. Apparent clustering of functions effecting rapid inhibition of host DNA and protein synthesis

M. Fenwick, Lawrence S Morse, B. Roizman

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Herpes simplex virus type 2 (HSV-2) strains inhibit the synthesis of both DNA and protein of the host cell more rapidly than HSV-1 strains. Several intertypic HSV-1 x HSV-2 recombinants and parental strains were examined for their ability to inhibit rapidly the synthesis of host protein and DNA. The two functions cosegregated in all of eight recombinants tested and are therefore controlled by the same gene or by different genes in the same region of the viral DNA.

Original languageEnglish (US)
Pages (from-to)825-827
Number of pages3
JournalJournal of Virology
Volume29
Issue number2
StatePublished - 1979
Externally publishedYes

Fingerprint

herpes simplex
DNA viruses
Human Herpesvirus 2
Human Herpesvirus 1
Simplexvirus
Human herpesvirus 2
Cluster Analysis
Anatomy
protein synthesis
DNA
Viral DNA
Genes
Proteins
synthesis
genes
proteins
cells

ASJC Scopus subject areas

  • Immunology

Cite this

Anatomy of Herpes simplex virus DNA. XI. Apparent clustering of functions effecting rapid inhibition of host DNA and protein synthesis. / Fenwick, M.; Morse, Lawrence S; Roizman, B.

In: Journal of Virology, Vol. 29, No. 2, 1979, p. 825-827.

Research output: Contribution to journalArticle

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