Anaplastic large cell lymphoma associated with Sjogren's syndrome

Hiroto Inaba, Hajime Kawasaki, Shigeo Nakamura, Hatsumi Yamamoto, Yasuhiko Kaneko, Noriko Satake, Yoshihiro Komada, Masahiro Ito, Minoru Sakurai

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4 Scopus citations

Abstract

We report a case of a 20-year-old Japanese female with recurrent anaplastic large cell lymphoma (ALCL) associated with Sjogren's syndrome (SjS). She was first diagnosed to have ALCL presenting with axillary lymphadenopathy, which within a month underwent spontaneous remission, at the age of 12 years. Eight years later she developed left inguinal lymphadenopathy with clinical overt sicca symptoms associated with elevated serum IgG, interleukin (IL)-1β and IL-6 levels. Lymph node biopsy was now diagnostic of ALCL characterized by large pleomorphic CD30+ blast cells with the specific chromosomal abnormality, t(2;5)(p23:q35). In contrast to this the salivary gland and renal biopsy revealed infiltration of small lymphocytes, morphologically and cytogenetically distinct from the ALCL cells. Interestingly, SjS symptomatology correlated with disease activity of ALCL and based on an association with elevated IgG and IL-6 levels, suggesting that the concurrence of these two diseases could be more than coincidental. To the best of our knowledge, this is the first reported case of ALCL presenting concurrently with SjS.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalLeukemia and Lymphoma
Volume32
Issue number1-2
StatePublished - 1998
Externally publishedYes

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Keywords

  • Anaplastic large cell lymphoma
  • Cytokine
  • Immunoglobulin
  • Non-Hodgkin's lymphoma
  • Sjogren's syndrome

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Inaba, H., Kawasaki, H., Nakamura, S., Yamamoto, H., Kaneko, Y., Satake, N., Komada, Y., Ito, M., & Sakurai, M. (1998). Anaplastic large cell lymphoma associated with Sjogren's syndrome. Leukemia and Lymphoma, 32(1-2), 183-188.