Anaphylactic events observed within 4 h of ocular application of an antibiotic-containing ophthalmic preparation

61 cats (1993-2010)

Karen M. Hume-Smith, Allyson D. Groth, Mark Rishniw, Linda A. Walter-Grimm, Signe J. Plunkett, David J Maggs

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This study describes signalment, history, antibiotic administered, clinical signs observed, therapy, and outcome of anaphylactic events within 4 h following ophthalmic administration of an antibiotic to cats. Data came from survey responses (45 cats) or Federal Drug Administration reports (16 cats). Cat age (7 weeks-19 years), breed, and gender ranged widely. Most were healthy (87%) prior to anaphylaxis. Ophthalmic antibiotics commonly were administered for conjunctival (65%) or corneal (11%) disease, or ocular lubrication (7%) and contained bacitracin, neomycin, and polymyxin B (44%), or oxytetracycline and polymyxin B (21%). Polymyxin B was present in all cases. Vaccines or other drugs were also administered to 51% of cats. In 56% cases, anaphylaxis occurred within 10 min of drug application. Most (82%) cats survived. Although a causal association was not proved, ophthalmic antibiotic administration preceded anaphylaxis in all cats. Like other drugs, ophthalmic antibiotics should be used only when indicated.

Original languageEnglish (US)
Pages (from-to)744-751
Number of pages8
JournalJournal of Feline Medicine and Surgery
Volume13
Issue number10
DOIs
StatePublished - Oct 2011

Fingerprint

Cats
eyes
antibiotics
cats
Anti-Bacterial Agents
polymyxin B
anaphylaxis
Ophthalmic Administration
Anaphylaxis
Polymyxin B
drugs
Pharmaceutical Preparations
Corneal Diseases
Lubrication
bacitracin
Oxytetracycline
neomycin
oxytetracycline
Vaccines
History

ASJC Scopus subject areas

  • Small Animals

Cite this

Anaphylactic events observed within 4 h of ocular application of an antibiotic-containing ophthalmic preparation : 61 cats (1993-2010). / Hume-Smith, Karen M.; Groth, Allyson D.; Rishniw, Mark; Walter-Grimm, Linda A.; Plunkett, Signe J.; Maggs, David J.

In: Journal of Feline Medicine and Surgery, Vol. 13, No. 10, 10.2011, p. 744-751.

Research output: Contribution to journalArticle

Hume-Smith, Karen M. ; Groth, Allyson D. ; Rishniw, Mark ; Walter-Grimm, Linda A. ; Plunkett, Signe J. ; Maggs, David J. / Anaphylactic events observed within 4 h of ocular application of an antibiotic-containing ophthalmic preparation : 61 cats (1993-2010). In: Journal of Feline Medicine and Surgery. 2011 ; Vol. 13, No. 10. pp. 744-751.
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