Abstract
This study describes signalment, history, antibiotic administered, clinical signs observed, therapy, and outcome of anaphylactic events within 4 h following ophthalmic administration of an antibiotic to cats. Data came from survey responses (45 cats) or Federal Drug Administration reports (16 cats). Cat age (7 weeks-19 years), breed, and gender ranged widely. Most were healthy (87%) prior to anaphylaxis. Ophthalmic antibiotics commonly were administered for conjunctival (65%) or corneal (11%) disease, or ocular lubrication (7%) and contained bacitracin, neomycin, and polymyxin B (44%), or oxytetracycline and polymyxin B (21%). Polymyxin B was present in all cases. Vaccines or other drugs were also administered to 51% of cats. In 56% cases, anaphylaxis occurred within 10 min of drug application. Most (82%) cats survived. Although a causal association was not proved, ophthalmic antibiotic administration preceded anaphylaxis in all cats. Like other drugs, ophthalmic antibiotics should be used only when indicated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 744-751 |
| Number of pages | 8 |
| Journal | Journal of Feline Medicine and Surgery |
| Volume | 13 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2011 |
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ASJC Scopus subject areas
- Small Animals
Cite this
Anaphylactic events observed within 4 h of ocular application of an antibiotic-containing ophthalmic preparation : 61 cats (1993-2010). / Hume-Smith, Karen M.; Groth, Allyson D.; Rishniw, Mark; Walter-Grimm, Linda A.; Plunkett, Signe J.; Maggs, David J.
In: Journal of Feline Medicine and Surgery, Vol. 13, No. 10, 10.2011, p. 744-751.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Anaphylactic events observed within 4 h of ocular application of an antibiotic-containing ophthalmic preparation
T2 - 61 cats (1993-2010)
AU - Hume-Smith, Karen M.
AU - Groth, Allyson D.
AU - Rishniw, Mark
AU - Walter-Grimm, Linda A.
AU - Plunkett, Signe J.
AU - Maggs, David J
PY - 2011/10
Y1 - 2011/10
N2 - This study describes signalment, history, antibiotic administered, clinical signs observed, therapy, and outcome of anaphylactic events within 4 h following ophthalmic administration of an antibiotic to cats. Data came from survey responses (45 cats) or Federal Drug Administration reports (16 cats). Cat age (7 weeks-19 years), breed, and gender ranged widely. Most were healthy (87%) prior to anaphylaxis. Ophthalmic antibiotics commonly were administered for conjunctival (65%) or corneal (11%) disease, or ocular lubrication (7%) and contained bacitracin, neomycin, and polymyxin B (44%), or oxytetracycline and polymyxin B (21%). Polymyxin B was present in all cases. Vaccines or other drugs were also administered to 51% of cats. In 56% cases, anaphylaxis occurred within 10 min of drug application. Most (82%) cats survived. Although a causal association was not proved, ophthalmic antibiotic administration preceded anaphylaxis in all cats. Like other drugs, ophthalmic antibiotics should be used only when indicated.
AB - This study describes signalment, history, antibiotic administered, clinical signs observed, therapy, and outcome of anaphylactic events within 4 h following ophthalmic administration of an antibiotic to cats. Data came from survey responses (45 cats) or Federal Drug Administration reports (16 cats). Cat age (7 weeks-19 years), breed, and gender ranged widely. Most were healthy (87%) prior to anaphylaxis. Ophthalmic antibiotics commonly were administered for conjunctival (65%) or corneal (11%) disease, or ocular lubrication (7%) and contained bacitracin, neomycin, and polymyxin B (44%), or oxytetracycline and polymyxin B (21%). Polymyxin B was present in all cases. Vaccines or other drugs were also administered to 51% of cats. In 56% cases, anaphylaxis occurred within 10 min of drug application. Most (82%) cats survived. Although a causal association was not proved, ophthalmic antibiotic administration preceded anaphylaxis in all cats. Like other drugs, ophthalmic antibiotics should be used only when indicated.
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U2 - 10.1016/j.jfms.2011.06.007
DO - 10.1016/j.jfms.2011.06.007
M3 - Article
VL - 13
SP - 744
EP - 751
JO - Journal of Feline Medicine and Surgery
JF - Journal of Feline Medicine and Surgery
SN - 1098-612X
IS - 10
ER -