Analytical metabolomics: Nutritional opportunities for personalized health

Elizabeth M S McNiven, J. Bruce German, Carolyn M. Slupsky

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Nutrition is the cornerstone of health; survival depends on acquiring essential nutrients, and dietary components can both prevent and promote disease. Metabolomics, the study of all small molecule metabolic products in a system, has been shown to provide a detailed snapshot of the body's processes at any particular point in time, opening up the possibility of monitoring health and disease, prevention and treatment. Metabolomics has the potential to fundamentally change clinical chemistry and, by extension, the fields of nutrition, toxicology and medicine. Technological advances, combined with new knowledge of the human genome and gut microbiome, have made and will continue to make possible earlier, more accurate, less invasive diagnoses, all while enhancing our understanding of the root causes of disease and leading to a generation of dietary recommendations that enable optimal health. This article reviews the recent contributions of metabolomics to the fields of nutrition, toxicology and medicine. It is expected that these fields will eventually blend together through development of new technologies in metabolomics and genomics into a new area of clinical chemistry: personalized medicine.

Original languageEnglish (US)
Pages (from-to)995-1002
Number of pages8
JournalJournal of Nutritional Biochemistry
Volume22
Issue number11
DOIs
StatePublished - Nov 2011

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Keywords

  • Clinical chemistry
  • Metabolomics
  • Nutrition
  • Personalized medicine
  • Toxicology

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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