Analysis of the CYP2D6 gene polymorphism and enzyme activity in African-Americans in Southern California

Yu-Jui Yvonne Wan, R. E. Poland, G. Han, T. Konishi, Y. P. Zheng, N. Berman, K. M. Lin

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Despite its importance in drug metabolism and disease susceptibility, CYP2D6 activity and genetic polymorphism have rarely been investigated in African-American populations. In order to bridge this gap, we examined the genotype and phenotype of the enzyme in 154 African-American (AA) and 143 Caucasian (C) normal volunteers. AAs are significantly more likely to possess *17 and *5, but less likely to have *4. Overall, the two groups were similar in their CYP2D6 activity as measured with dextromethorphan as the probe (metabolic ratio 2.21 ± 0.78 for AAs; 2.11 ± 0.86 for Cs; t = 1.02, NS). Two of four AAs and six of seven Cs were classified as poor metabolizers and have two nonfunctioning alleles. CYP2D6 activity is determined by *17, *4, *5 and age in AAs (r2 = 0.33, f = 18.8, P < 0.001) and by *4 and *XN in Cs (r2 = 0.14, f = 10.8, P < 0.001). These results support previous findings demonstrating the importance of *17 in determining CYP2D6 activity in AAs.

Original languageEnglish (US)
Pages (from-to)489-499
Number of pages11
JournalPharmacogenetics
Volume11
Issue number6
DOIs
StatePublished - 2001

Keywords

  • African-American
  • CYP2D6
  • Dextromethorphan
  • Polymorphism

ASJC Scopus subject areas

  • Genetics
  • Pharmacology, Toxicology and Pharmaceutics(all)

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