Analysis of skeletal muscle hypertrophy in models of increased loading

Sue C. Bodine, Keith Baar

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Scopus citations

Abstract

Skeletal muscle is a highly adaptive tissue that modifies its size in response to a variety of external stimuli. In adult mammals, skeletal muscle hypertrophy occurs primarily as a response to increases in external loading. Here, we describe the methods that should be used for a comprehensive assessment of muscle hypertrophy in animal models. The methods include the measurement of muscle mass, fiber cross-sectional area, contractile function, and protein concentration.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
Pages213-229
Number of pages17
Volume798
DOIs
StatePublished - 2012

Publication series

NameMethods in Molecular Biology
Volume798
ISSN (Print)10643745

Keywords

  • Isometric maximal force
  • Muscle hypertrophy
  • Physiological cross-sectional area
  • Resistance exercise
  • Specific tension

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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    Bodine, S. C., & Baar, K. (2012). Analysis of skeletal muscle hypertrophy in models of increased loading. In Methods in Molecular Biology (Vol. 798, pp. 213-229). (Methods in Molecular Biology; Vol. 798). https://doi.org/10.1007/978-1-61779-343-1_12