Abstract
Skeletal muscle is a highly adaptive tissue that modifies its size in response to a variety of external stimuli. In adult mammals, skeletal muscle hypertrophy occurs primarily as a response to increases in external loading. Here, we describe the methods that should be used for a comprehensive assessment of muscle hypertrophy in animal models. The methods include the measurement of muscle mass, fiber cross-sectional area, contractile function, and protein concentration.
| Original language | English (US) |
|---|---|
| Title of host publication | Methods in Molecular Biology |
| Pages | 213-229 |
| Number of pages | 17 |
| Volume | 798 |
| DOIs | |
| State | Published - 2012 |
Publication series
| Name | Methods in Molecular Biology |
|---|---|
| Volume | 798 |
| ISSN (Print) | 10643745 |
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Keywords
- Isometric maximal force
- Muscle hypertrophy
- Physiological cross-sectional area
- Resistance exercise
- Specific tension
ASJC Scopus subject areas
- Molecular Biology
- Genetics
Cite this
Analysis of skeletal muscle hypertrophy in models of increased loading. / Bodine, Sue C.; Baar, Keith.
Methods in Molecular Biology. Vol. 798 2012. p. 213-229 (Methods in Molecular Biology; Vol. 798).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Analysis of skeletal muscle hypertrophy in models of increased loading
AU - Bodine, Sue C.
AU - Baar, Keith
PY - 2012
Y1 - 2012
N2 - Skeletal muscle is a highly adaptive tissue that modifies its size in response to a variety of external stimuli. In adult mammals, skeletal muscle hypertrophy occurs primarily as a response to increases in external loading. Here, we describe the methods that should be used for a comprehensive assessment of muscle hypertrophy in animal models. The methods include the measurement of muscle mass, fiber cross-sectional area, contractile function, and protein concentration.
AB - Skeletal muscle is a highly adaptive tissue that modifies its size in response to a variety of external stimuli. In adult mammals, skeletal muscle hypertrophy occurs primarily as a response to increases in external loading. Here, we describe the methods that should be used for a comprehensive assessment of muscle hypertrophy in animal models. The methods include the measurement of muscle mass, fiber cross-sectional area, contractile function, and protein concentration.
KW - Isometric maximal force
KW - Muscle hypertrophy
KW - Physiological cross-sectional area
KW - Resistance exercise
KW - Specific tension
UR - http://www.scopus.com/inward/record.url?scp=84555188361&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84555188361&partnerID=8YFLogxK
U2 - 10.1007/978-1-61779-343-1_12
DO - 10.1007/978-1-61779-343-1_12
M3 - Chapter
C2 - 22130839
AN - SCOPUS:84555188361
SN - 9781617793424
VL - 798
T3 - Methods in Molecular Biology
SP - 213
EP - 229
BT - Methods in Molecular Biology
ER -