Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies

Maciej Szkulmowski, Maciej Wojtkowski, Bartosz Sikorski, Tomasz Bajraszewski, Vivek Srinivasan, Anna Szkulmowska, Jakub J. KaluSny, James G. Fujimoto, Andrzej Kowalczyk

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

We present a computationally efficient, semiautomated method for analysis of posterior retinal layers in three-dimensional (3-D) images obtained by spectral optical coherence tomography (SOCT). The method consists of two steps: segmentation of posterior retinal layers and analysis of their thickness and distance from an outer retinal contour (ORC), which is introduced to approximate the normal position of external interface of the healthy retinal pigment epithelium (RPE). The algorithm is shown to effectively segment posterior retina by classifying every pixel in the SOCT tomogram using the similarity of its surroundings to a reference set of model pixels from user-selected area(s). Operator intervention is required to assess the quality of segmentation. Thickness and distance maps from the segmented layers and their analysis are presented for healthy and pathological retinas.

Original languageEnglish (US)
Article number041207
JournalJournal of Biomedical Optics
Volume12
Issue number4
DOIs
StatePublished - Jul 1 2007
Externally publishedYes

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retina
Optical tomography
pathology
Pathology
tomography
Pixels
Retinal Pigments
pixels
Pigments
epithelium
pigments
classifying
operators

Keywords

  • Image analysis
  • Image segmentation
  • Optical coherence tomography (OCT)
  • Spectral optical coherence tomography (SOCT)

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies. / Szkulmowski, Maciej; Wojtkowski, Maciej; Sikorski, Bartosz; Bajraszewski, Tomasz; Srinivasan, Vivek; Szkulmowska, Anna; KaluSny, Jakub J.; Fujimoto, James G.; Kowalczyk, Andrzej.

In: Journal of Biomedical Optics, Vol. 12, No. 4, 041207, 01.07.2007.

Research output: Contribution to journalArticle

Szkulmowski, M, Wojtkowski, M, Sikorski, B, Bajraszewski, T, Srinivasan, V, Szkulmowska, A, KaluSny, JJ, Fujimoto, JG & Kowalczyk, A 2007, 'Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies', Journal of Biomedical Optics, vol. 12, no. 4, 041207. https://doi.org/10.1117/1.2771569
Szkulmowski, Maciej ; Wojtkowski, Maciej ; Sikorski, Bartosz ; Bajraszewski, Tomasz ; Srinivasan, Vivek ; Szkulmowska, Anna ; KaluSny, Jakub J. ; Fujimoto, James G. ; Kowalczyk, Andrzej. / Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies. In: Journal of Biomedical Optics. 2007 ; Vol. 12, No. 4.
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