Analysis of organic acids, amino acids, and carnitine in dogs with lipid storage myopathy

G. Diane Shelton, William L. Nyhan, Philip H Kass, Bruce A. Barshop, Richard H. Haas

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Abnormal accumulations of lipid droplets, localized predominantly in histochemical type I fibers, were observed in fresh frozen sections of muscle biopsies from 25 dogs with myalgia, weakness, and muscle atrophy. Compared to controls, lactic acidemia, hyperalaninemia, lactic and pyruvic aciduria, variably increased urinary excretion of carnitine esters, and muscle carnitine deficiency were present. These findings support a metabolic block in oxidative metabolism resulting in lactic acidemia in dogs with lipid storage myopathy.

Original languageEnglish (US)
Pages (from-to)1202-1205
Number of pages4
JournalMuscle and Nerve
Volume21
Issue number9
DOIs
StatePublished - Sep 1998

Fingerprint

Milk
Carnitine
Dogs
Amino Acids
Acids
Muscles
Muscular Atrophy
Myalgia
Frozen Sections
Esters
Biopsy
Myopathy with Abnormal Lipid Metabolism
emeriamine
Hyper-Beta-Alaninemia
Lipid Droplets

Keywords

  • Canine
  • Carnitine
  • Laotic acidemia
  • Lipid storage
  • Myopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Analysis of organic acids, amino acids, and carnitine in dogs with lipid storage myopathy. / Shelton, G. Diane; Nyhan, William L.; Kass, Philip H; Barshop, Bruce A.; Haas, Richard H.

In: Muscle and Nerve, Vol. 21, No. 9, 09.1998, p. 1202-1205.

Research output: Contribution to journalArticle

Shelton, G. Diane ; Nyhan, William L. ; Kass, Philip H ; Barshop, Bruce A. ; Haas, Richard H. / Analysis of organic acids, amino acids, and carnitine in dogs with lipid storage myopathy. In: Muscle and Nerve. 1998 ; Vol. 21, No. 9. pp. 1202-1205.
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