Analysis of organic acids, amino acids, and carnitine in dogs with lipid storage myopathy

G. Diane Shelton, William L. Nyhan, Philip H Kass, Bruce A. Barshop, Richard H. Haas

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Abnormal accumulations of lipid droplets, localized predominantly in histochemical type I fibers, were observed in fresh frozen sections of muscle biopsies from 25 dogs with myalgia, weakness, and muscle atrophy. Compared to controls, lactic acidemia, hyperalaninemia, lactic and pyruvic aciduria, variably increased urinary excretion of carnitine esters, and muscle carnitine deficiency were present. These findings support a metabolic block in oxidative metabolism resulting in lactic acidemia in dogs with lipid storage myopathy.

Original languageEnglish (US)
Pages (from-to)1202-1205
Number of pages4
JournalMuscle and Nerve
Volume21
Issue number9
DOIs
StatePublished - Sep 1998

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Keywords

  • Canine
  • Carnitine
  • Laotic acidemia
  • Lipid storage
  • Myopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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