Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis

Christopher Bowlus, Tom H. Karlsen, Ulrika Broomé, Erik Thorsby, Morten Vatn, Erik Schrumpf, Benedicte A. Lie, Kirsten Muri Boberg

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background/Aims: Mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) has been implicated in the aberrant homing of intestinal lymphocytes to the liver in primary sclerosing cholangitis (PSC). Intercellular adhesion molecule-1 (ICAM-1) has also been implicated in the pathogenesis of PSC and the E/E genotype of the K469E polymorphism has been reported to be associated with PSC susceptibility. The aims of this study were to determine if MAdCAM-1 polymorphisms or the K469E polymorphism of ICAM-1 are associated with PSC in Scandinavia. Methods: Seven single nucleotide polymorphisms (SNPs) in MAdCAM-1 and the G421R and K469E ICAM-1 SNPs were genotyped in 365 PSC patients from Norway and Sweden. 327 Norwegian ulcerative colitis (UC) patients and 368 Norwegian bone marrow donors served as controls. Results: No significant association with PSC was found for any of the MAdCAM-1 or ICAM-1 SNPs. Allele frequencies for these polymorphisms were not significantly different between PSC patients with UC, UC patients and healthy controls. Conclusions: Polymorphisms in MAdCAM-1 are not likely to significantly affect PSC susceptibility. In addition, the E/E genotype of the K469E in ICAM-1 does not influence PSC susceptibility in Scandinavia.

Original languageEnglish (US)
Pages (from-to)704-710
Number of pages7
JournalJournal of Hepatology
Volume45
Issue number5
DOIs
StatePublished - Nov 2006

Fingerprint

Sclerosing Cholangitis
Intercellular Adhesion Molecule-1
Ulcerative Colitis
Scandinavian and Nordic Countries
Single Nucleotide Polymorphism
Genotype
Norway
Sweden
Gene Frequency
Bone Marrow
Tissue Donors
Lymphocytes
Liver

Keywords

  • Cholangiocarcinoma
  • Genetics
  • Human leukocyte antigen
  • Inflammatory bowel disease
  • Intercellular adhesion molecule-1
  • Mucosal addressin cellular adhesion molecule-1
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis. / Bowlus, Christopher; Karlsen, Tom H.; Broomé, Ulrika; Thorsby, Erik; Vatn, Morten; Schrumpf, Erik; Lie, Benedicte A.; Boberg, Kirsten Muri.

In: Journal of Hepatology, Vol. 45, No. 5, 11.2006, p. 704-710.

Research output: Contribution to journalArticle

Bowlus, C, Karlsen, TH, Broomé, U, Thorsby, E, Vatn, M, Schrumpf, E, Lie, BA & Boberg, KM 2006, 'Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis', Journal of Hepatology, vol. 45, no. 5, pp. 704-710. https://doi.org/10.1016/j.jhep.2006.03.012
Bowlus, Christopher ; Karlsen, Tom H. ; Broomé, Ulrika ; Thorsby, Erik ; Vatn, Morten ; Schrumpf, Erik ; Lie, Benedicte A. ; Boberg, Kirsten Muri. / Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis. In: Journal of Hepatology. 2006 ; Vol. 45, No. 5. pp. 704-710.
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AU - Thorsby, Erik

AU - Vatn, Morten

AU - Schrumpf, Erik

AU - Lie, Benedicte A.

AU - Boberg, Kirsten Muri

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N2 - Background/Aims: Mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) has been implicated in the aberrant homing of intestinal lymphocytes to the liver in primary sclerosing cholangitis (PSC). Intercellular adhesion molecule-1 (ICAM-1) has also been implicated in the pathogenesis of PSC and the E/E genotype of the K469E polymorphism has been reported to be associated with PSC susceptibility. The aims of this study were to determine if MAdCAM-1 polymorphisms or the K469E polymorphism of ICAM-1 are associated with PSC in Scandinavia. Methods: Seven single nucleotide polymorphisms (SNPs) in MAdCAM-1 and the G421R and K469E ICAM-1 SNPs were genotyped in 365 PSC patients from Norway and Sweden. 327 Norwegian ulcerative colitis (UC) patients and 368 Norwegian bone marrow donors served as controls. Results: No significant association with PSC was found for any of the MAdCAM-1 or ICAM-1 SNPs. Allele frequencies for these polymorphisms were not significantly different between PSC patients with UC, UC patients and healthy controls. Conclusions: Polymorphisms in MAdCAM-1 are not likely to significantly affect PSC susceptibility. In addition, the E/E genotype of the K469E in ICAM-1 does not influence PSC susceptibility in Scandinavia.

AB - Background/Aims: Mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) has been implicated in the aberrant homing of intestinal lymphocytes to the liver in primary sclerosing cholangitis (PSC). Intercellular adhesion molecule-1 (ICAM-1) has also been implicated in the pathogenesis of PSC and the E/E genotype of the K469E polymorphism has been reported to be associated with PSC susceptibility. The aims of this study were to determine if MAdCAM-1 polymorphisms or the K469E polymorphism of ICAM-1 are associated with PSC in Scandinavia. Methods: Seven single nucleotide polymorphisms (SNPs) in MAdCAM-1 and the G421R and K469E ICAM-1 SNPs were genotyped in 365 PSC patients from Norway and Sweden. 327 Norwegian ulcerative colitis (UC) patients and 368 Norwegian bone marrow donors served as controls. Results: No significant association with PSC was found for any of the MAdCAM-1 or ICAM-1 SNPs. Allele frequencies for these polymorphisms were not significantly different between PSC patients with UC, UC patients and healthy controls. Conclusions: Polymorphisms in MAdCAM-1 are not likely to significantly affect PSC susceptibility. In addition, the E/E genotype of the K469E in ICAM-1 does not influence PSC susceptibility in Scandinavia.

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