Abstract
Background/Aims: Mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) has been implicated in the aberrant homing of intestinal lymphocytes to the liver in primary sclerosing cholangitis (PSC). Intercellular adhesion molecule-1 (ICAM-1) has also been implicated in the pathogenesis of PSC and the E/E genotype of the K469E polymorphism has been reported to be associated with PSC susceptibility. The aims of this study were to determine if MAdCAM-1 polymorphisms or the K469E polymorphism of ICAM-1 are associated with PSC in Scandinavia. Methods: Seven single nucleotide polymorphisms (SNPs) in MAdCAM-1 and the G421R and K469E ICAM-1 SNPs were genotyped in 365 PSC patients from Norway and Sweden. 327 Norwegian ulcerative colitis (UC) patients and 368 Norwegian bone marrow donors served as controls. Results: No significant association with PSC was found for any of the MAdCAM-1 or ICAM-1 SNPs. Allele frequencies for these polymorphisms were not significantly different between PSC patients with UC, UC patients and healthy controls. Conclusions: Polymorphisms in MAdCAM-1 are not likely to significantly affect PSC susceptibility. In addition, the E/E genotype of the K469E in ICAM-1 does not influence PSC susceptibility in Scandinavia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 704-710 |
| Number of pages | 7 |
| Journal | Journal of Hepatology |
| Volume | 45 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 2006 |
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Keywords
- Cholangiocarcinoma
- Genetics
- Human leukocyte antigen
- Inflammatory bowel disease
- Intercellular adhesion molecule-1
- Mucosal addressin cellular adhesion molecule-1
- Primary sclerosing cholangitis
ASJC Scopus subject areas
- Gastroenterology
Cite this
Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis. / Bowlus, Christopher; Karlsen, Tom H.; Broomé, Ulrika; Thorsby, Erik; Vatn, Morten; Schrumpf, Erik; Lie, Benedicte A.; Boberg, Kirsten Muri.
In: Journal of Hepatology, Vol. 45, No. 5, 11.2006, p. 704-710.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis
AU - Bowlus, Christopher
AU - Karlsen, Tom H.
AU - Broomé, Ulrika
AU - Thorsby, Erik
AU - Vatn, Morten
AU - Schrumpf, Erik
AU - Lie, Benedicte A.
AU - Boberg, Kirsten Muri
PY - 2006/11
Y1 - 2006/11
N2 - Background/Aims: Mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) has been implicated in the aberrant homing of intestinal lymphocytes to the liver in primary sclerosing cholangitis (PSC). Intercellular adhesion molecule-1 (ICAM-1) has also been implicated in the pathogenesis of PSC and the E/E genotype of the K469E polymorphism has been reported to be associated with PSC susceptibility. The aims of this study were to determine if MAdCAM-1 polymorphisms or the K469E polymorphism of ICAM-1 are associated with PSC in Scandinavia. Methods: Seven single nucleotide polymorphisms (SNPs) in MAdCAM-1 and the G421R and K469E ICAM-1 SNPs were genotyped in 365 PSC patients from Norway and Sweden. 327 Norwegian ulcerative colitis (UC) patients and 368 Norwegian bone marrow donors served as controls. Results: No significant association with PSC was found for any of the MAdCAM-1 or ICAM-1 SNPs. Allele frequencies for these polymorphisms were not significantly different between PSC patients with UC, UC patients and healthy controls. Conclusions: Polymorphisms in MAdCAM-1 are not likely to significantly affect PSC susceptibility. In addition, the E/E genotype of the K469E in ICAM-1 does not influence PSC susceptibility in Scandinavia.
AB - Background/Aims: Mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) has been implicated in the aberrant homing of intestinal lymphocytes to the liver in primary sclerosing cholangitis (PSC). Intercellular adhesion molecule-1 (ICAM-1) has also been implicated in the pathogenesis of PSC and the E/E genotype of the K469E polymorphism has been reported to be associated with PSC susceptibility. The aims of this study were to determine if MAdCAM-1 polymorphisms or the K469E polymorphism of ICAM-1 are associated with PSC in Scandinavia. Methods: Seven single nucleotide polymorphisms (SNPs) in MAdCAM-1 and the G421R and K469E ICAM-1 SNPs were genotyped in 365 PSC patients from Norway and Sweden. 327 Norwegian ulcerative colitis (UC) patients and 368 Norwegian bone marrow donors served as controls. Results: No significant association with PSC was found for any of the MAdCAM-1 or ICAM-1 SNPs. Allele frequencies for these polymorphisms were not significantly different between PSC patients with UC, UC patients and healthy controls. Conclusions: Polymorphisms in MAdCAM-1 are not likely to significantly affect PSC susceptibility. In addition, the E/E genotype of the K469E in ICAM-1 does not influence PSC susceptibility in Scandinavia.
KW - Cholangiocarcinoma
KW - Genetics
KW - Human leukocyte antigen
KW - Inflammatory bowel disease
KW - Intercellular adhesion molecule-1
KW - Mucosal addressin cellular adhesion molecule-1
KW - Primary sclerosing cholangitis
UR - http://www.scopus.com/inward/record.url?scp=33749068247&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749068247&partnerID=8YFLogxK
U2 - 10.1016/j.jhep.2006.03.012
DO - 10.1016/j.jhep.2006.03.012
M3 - Article
C2 - 16750586
AN - SCOPUS:33749068247
VL - 45
SP - 704
EP - 710
JO - Journal of Hepatology
JF - Journal of Hepatology
SN - 0168-8278
IS - 5
ER -