Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis

Christopher Bowlus, Tom H. Karlsen, Ulrika Broomé, Erik Thorsby, Morten Vatn, Erik Schrumpf, Benedicte A. Lie, Kirsten Muri Boberg

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Background/Aims: Mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) has been implicated in the aberrant homing of intestinal lymphocytes to the liver in primary sclerosing cholangitis (PSC). Intercellular adhesion molecule-1 (ICAM-1) has also been implicated in the pathogenesis of PSC and the E/E genotype of the K469E polymorphism has been reported to be associated with PSC susceptibility. The aims of this study were to determine if MAdCAM-1 polymorphisms or the K469E polymorphism of ICAM-1 are associated with PSC in Scandinavia. Methods: Seven single nucleotide polymorphisms (SNPs) in MAdCAM-1 and the G421R and K469E ICAM-1 SNPs were genotyped in 365 PSC patients from Norway and Sweden. 327 Norwegian ulcerative colitis (UC) patients and 368 Norwegian bone marrow donors served as controls. Results: No significant association with PSC was found for any of the MAdCAM-1 or ICAM-1 SNPs. Allele frequencies for these polymorphisms were not significantly different between PSC patients with UC, UC patients and healthy controls. Conclusions: Polymorphisms in MAdCAM-1 are not likely to significantly affect PSC susceptibility. In addition, the E/E genotype of the K469E in ICAM-1 does not influence PSC susceptibility in Scandinavia.

Original languageEnglish (US)
Pages (from-to)704-710
Number of pages7
JournalJournal of Hepatology
Volume45
Issue number5
DOIs
StatePublished - Nov 2006

Keywords

  • Cholangiocarcinoma
  • Genetics
  • Human leukocyte antigen
  • Inflammatory bowel disease
  • Intercellular adhesion molecule-1
  • Mucosal addressin cellular adhesion molecule-1
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Gastroenterology

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    Bowlus, C., Karlsen, T. H., Broomé, U., Thorsby, E., Vatn, M., Schrumpf, E., Lie, B. A., & Boberg, K. M. (2006). Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis. Journal of Hepatology, 45(5), 704-710. https://doi.org/10.1016/j.jhep.2006.03.012