Analysis of Genetic Variation in 28 Dog Breed Populations with 100 Microsatellite Markers

Dawn N. Irion, A. L. Schaffer, T. R. Famula, M. L. Eggleston, S. S. Hughes, Niels C Pedersen

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Dog breeds were created by man choosing for select phenotypic traits such as size, shape, coat color, conformation, and behavior. Rigorous phenotypic selection likely resulted in a loss of genetic information. The present study extends previous dog population observations by assessing the genotypic variation within and across 28 breeds representing the seven recognized breed groups of the American Kennel Club (AKC). One hundred autosomal microsatellite markers distributed across the canine genome were used to examine variation within breeds. Resulting breed-specific allele frequencies were then used in an attempt to elucidate phylogeny and genetic distances between breeds. While the set of autosomal microsatellites was useful in describing genetic variation within breeds, establishing the genetic relatedness between breeds was less conclusive. A more accurate determination of breed phylogeny will likely require the use of single-nucleotide polymorphisms (SNPs).

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalJournal of Heredity
Volume94
Issue number1
DOIs
StatePublished - Jan 2003

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Phylogeny
dog breeds
Microsatellite Repeats
Dogs
microsatellite repeats
breeds
genetic variation
Gene Frequency
Population
Single Nucleotide Polymorphism
Canidae
Color
Genome
dogs
phylogeny
single nucleotide polymorphism
genetic relationships
gene frequency
genetic distance
genome

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

Analysis of Genetic Variation in 28 Dog Breed Populations with 100 Microsatellite Markers. / Irion, Dawn N.; Schaffer, A. L.; Famula, T. R.; Eggleston, M. L.; Hughes, S. S.; Pedersen, Niels C.

In: Journal of Heredity, Vol. 94, No. 1, 01.2003, p. 81-87.

Research output: Contribution to journalArticle

Irion, Dawn N. ; Schaffer, A. L. ; Famula, T. R. ; Eggleston, M. L. ; Hughes, S. S. ; Pedersen, Niels C. / Analysis of Genetic Variation in 28 Dog Breed Populations with 100 Microsatellite Markers. In: Journal of Heredity. 2003 ; Vol. 94, No. 1. pp. 81-87.
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