Analysis of galanin and the galanin antagonist M40 on delayed non- matching-to-position performance in rats lesioned with the cholinergic immunotoxin 192IgG-saporin

Michael P. McDonald, Gary L. Wenk, Jacqueline Crawley

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Galanin is a 29-amino-acid neuropeptide that is overexpressed in Alzheimer's disease (AD) and impairs performance on rodent learning and memory tasks. M40, a peptidergic galanin receptor ligand, blocks galanin- induced impairments on delayed non-matching-to-position (DNMTP). The present experiments used the 192IgG-saporin lesion model of AD to evaluate the actions of galanin and M40 on DNMTP when cholinergic transmission was reduced. Hippocampal choline acetyltransferase levels were correlated with DNMTP choice accuracy in lesioned rats. Intracerebroventricular (icv) galanin reduced choice accuracy in both the lesioned and sham groups. M40 alone, either icv or intrahippocampal, did not affect choice accuracy in either group. These results suggest that excess galanin can produce further deficits in DNMTP performance in a lesion model of AD, but blocking endogenous galanin is not sufficient alone to improve performance in lesioned rats.

Original languageEnglish (US)
Pages (from-to)552-563
Number of pages12
JournalBehavioral Neuroscience
Volume111
Issue number3
DOIs
StatePublished - Jun 1997
Externally publishedYes

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Galanin
Immunotoxins
Cholinergic Agents
Alzheimer Disease
Galanin Receptors
Choline O-Acetyltransferase
Neuropeptides
saporin
M40
Rodentia
Learning
Ligands
Amino Acids

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

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abstract = "Galanin is a 29-amino-acid neuropeptide that is overexpressed in Alzheimer's disease (AD) and impairs performance on rodent learning and memory tasks. M40, a peptidergic galanin receptor ligand, blocks galanin- induced impairments on delayed non-matching-to-position (DNMTP). The present experiments used the 192IgG-saporin lesion model of AD to evaluate the actions of galanin and M40 on DNMTP when cholinergic transmission was reduced. Hippocampal choline acetyltransferase levels were correlated with DNMTP choice accuracy in lesioned rats. Intracerebroventricular (icv) galanin reduced choice accuracy in both the lesioned and sham groups. M40 alone, either icv or intrahippocampal, did not affect choice accuracy in either group. These results suggest that excess galanin can produce further deficits in DNMTP performance in a lesion model of AD, but blocking endogenous galanin is not sufficient alone to improve performance in lesioned rats.",
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