Analysis of clinical prognostic factors for adult patients with head and neck sarcomas

Amy E. Chang, Xiaoyu Chai, Seth M. Pollack, Elizabeth Loggers, Eve Rodler, Jasjit Dillon, Upendra Parvathaneni, Kris S. Moe, Neal Futran, Robin L. Jones

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Objective. To evaluate the treatment, outcome, and prognostic factors in patients with head and neck sarcomas treated in an academic medical center.

Study Design. Case series.

Setting. Academic medical center.

Subjects and Methods. We performed a retrospective analysis of adult patients (n = 97) with primary head and neck sarcomas treated between 2000 and 2012. We analyzed the treatment, outcome, and potential factors predictive of disease-free survival and disease-specific survival. We also evaluated the outcome and prognostic factors in patients with bone and soft tissue sarcomas.

Results. The median overall survival was 6.8 years, with 2- year and 5-year overall survival rates of 78% (95% confidence interval [CI], 66%-86%) and 59% (95% CI, 44%-72%), respectively. Univariable analysis revealed that age at diagnosis (.60 years: hazard ratio [HR], 2.7; 95% CI, 1.2-6.2; P = .01), surgical intervention (HR, 8.3; 95% CI, 3.5-19.5; P \.001), and metastatic disease (HR, 4.3; 95% CI, 1.3-13.6; P = .01) were significantly associated with disease-specific survival.

Conclusion. In this study, patients over the age of 60 years at diagnosis and those with inoperable disease at initial presentation had significantly worse disease-specific survival. Surgical intervention remains the optimal treatment modality for those with resectable disease and was associated with significantly better survival in this heterogeneous series. Further multi-institutional studies are required to better define prognostic factors in individual histological subtypes.

Original languageEnglish (US)
Pages (from-to)976-983
Number of pages8
JournalOtolaryngology - Head and Neck Surgery (United States)
Volume151
Issue number6
DOIs
StatePublished - Dec 4 2014
Externally publishedYes

Keywords

  • bone
  • head and neck
  • outcome
  • prognostic factors
  • sarcoma
  • soft tissue sarcoma

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery
  • Medicine(all)

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    Chang, A. E., Chai, X., Pollack, S. M., Loggers, E., Rodler, E., Dillon, J., Parvathaneni, U., Moe, K. S., Futran, N., & Jones, R. L. (2014). Analysis of clinical prognostic factors for adult patients with head and neck sarcomas. Otolaryngology - Head and Neck Surgery (United States), 151(6), 976-983. https://doi.org/10.1177/0194599814551539