Abstract
Host development of human anti-mouse antibodies (HAMA) in response to administered antibodies has been reported as a problem for antibody imaging and therapy However; radioimmunotherapy has been shown to be effective in patients with B-cell malignancies because their immunodeficient state precludes or delays development of a HAMA response to mouse antibodies. Baseline HAMA activity was assayed in 60 patients with B-lymphocytic non-Hodgkin's lymphoma or chronic lymphocytic leukemia and sequentially in 43 patients who were subsequently treated with radiolabeled Lym-1 antibody. Pre-existing 'HAMA' activity was found in 3 (5%) of the 60 patients screened for treatment consideration. The incidence of development of HAMA in the 43 patients treated with multiple doses of radiolabebed Lym-1 antibody was 12 (28%). There was no evidence for an anaphylactoid or related response in the HAMA positive patients. HAMA activity interrupted therapy in 14% of the patients (6 of 43) but did not preclude therapeutic responses to radiolabeled Lym-1 therapy. Median survival for the HAMA positive patients was longer (18 months) than for those who did not develop HAMA activity (9 months).
Original language | English (US) |
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Pages (from-to) | 67-74 |
Number of pages | 8 |
Journal | International Journal of Biological Markers |
Volume | 10 |
Issue number | 2 |
State | Published - 1995 |
Keywords
- Antiglobulin
- Chronic lymphocytic leukemia
- HAMA
- Lym-1
- Lymphoma
- Radioimmunotherapy
ASJC Scopus subject areas
- Immunology
- Biochemistry