Analysis of antiglobulin (HAMA) response in a group of patients with B-lympkocytic malignancies treated with 131I-Lym-1

Gerald L Denardo, L. A. Kroger, G. R. Mirick, K. R. Lamborn, S. J. De Nardo

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Host development of human anti-mouse antibodies (HAMA) in response to administered antibodies has been reported as a problem for antibody imaging and therapy However; radioimmunotherapy has been shown to be effective in patients with B-cell malignancies because their immunodeficient state precludes or delays development of a HAMA response to mouse antibodies. Baseline HAMA activity was assayed in 60 patients with B-lymphocytic non-Hodgkin's lymphoma or chronic lymphocytic leukemia and sequentially in 43 patients who were subsequently treated with radiolabeled Lym-1 antibody. Pre-existing 'HAMA' activity was found in 3 (5%) of the 60 patients screened for treatment consideration. The incidence of development of HAMA in the 43 patients treated with multiple doses of radiolabebed Lym-1 antibody was 12 (28%). There was no evidence for an anaphylactoid or related response in the HAMA positive patients. HAMA activity interrupted therapy in 14% of the patients (6 of 43) but did not preclude therapeutic responses to radiolabeled Lym-1 therapy. Median survival for the HAMA positive patients was longer (18 months) than for those who did not develop HAMA activity (9 months).

Original languageEnglish (US)
Pages (from-to)67-74
Number of pages8
JournalInternational Journal of Biological Markers
Volume10
Issue number2
StatePublished - 1995

Keywords

  • Antiglobulin
  • Chronic lymphocytic leukemia
  • HAMA
  • Lym-1
  • Lymphoma
  • Radioimmunotherapy

ASJC Scopus subject areas

  • Immunology
  • Biochemistry

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