Analgesic effects of intramuscular administration of meloxicam in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis

Gretchen A. Cole, Joanne R Paul-Murphy, Lisa Krugner-Higby, Julia M. Klauer, Scott E. Medlin, Nicholas S. Keuler, Kurt K. Sladky

Research output: Contribution to journalArticle

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Abstract

Objective - To evaluate the analgesic efficacy of meloxicam in parrots with experimentally induced arthritis, with extent of weight bearing and rotational perch walking used as outcome measures. Animals - 15 adult Hispaniolan parrots (Amazona ventralis). Procedures - Arthritis was experimentally induced via intra-articular injection of microcrystalline sodium urate suspension (MSU) into 1 intertarsal joint. Parrots were treated in a crossover design. Five treatments were compared as follows: meloxicam (4 dosages) at 0.05, 0.1, 0.5, and 1.0 mg/kg (IM, q 12 h, 3 times) and 0.03 mL of saline (0.9% NaCI) solution (IM, q 12 h, 3 times). The first treatment was given 6 hours following MSU administration. Lameness was assessed by use of a biomechanical perch to record weight-bearing load and a rotational perch to determine dexterity. Feces were collected to assay for occult blood. Results - Parrots treated with meloxicam at 1.0 mg/kg had significantly better return to normal (baseline) weight bearing on the arthritic pelvic limb, compared with control parrots or parrots treated with meloxicam at 0.05, 0.1, and 0.5 mg/kg. All fecal samples collected from parrots following induction of arthritis and treatment with meloxicam had negative results for occult blood. Conclusions and Clinical Relevance - Meloxicam administered at 1.0 mg/kg, IM, every 12 hours effectively relieved arthritic pain in parrots.

Original languageEnglish (US)
Pages (from-to)1471-1476
Number of pages6
JournalAmerican Journal of Veterinary Research
Volume70
Issue number12
DOIs
StatePublished - Dec 2009

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meloxicam
Amazona
Parrots
analgesic effect
parrots
arthritis
intramuscular injection
Arthritis
Analgesics
Perches
Weight-Bearing
perch
Occult Blood
Uric Acid
Suspensions
Tarsal Joints
sodium
Intra-Articular Injections
blood
analgesics

ASJC Scopus subject areas

  • veterinary(all)

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Analgesic effects of intramuscular administration of meloxicam in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis. / Cole, Gretchen A.; Paul-Murphy, Joanne R; Krugner-Higby, Lisa; Klauer, Julia M.; Medlin, Scott E.; Keuler, Nicholas S.; Sladky, Kurt K.

In: American Journal of Veterinary Research, Vol. 70, No. 12, 12.2009, p. 1471-1476.

Research output: Contribution to journalArticle

Cole, Gretchen A. ; Paul-Murphy, Joanne R ; Krugner-Higby, Lisa ; Klauer, Julia M. ; Medlin, Scott E. ; Keuler, Nicholas S. ; Sladky, Kurt K. / Analgesic effects of intramuscular administration of meloxicam in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis. In: American Journal of Veterinary Research. 2009 ; Vol. 70, No. 12. pp. 1471-1476.
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