Abstract
Objective - To evaluate the analgesic efficacy of meloxicam in parrots with experimentally induced arthritis, with extent of weight bearing and rotational perch walking used as outcome measures. Animals - 15 adult Hispaniolan parrots (Amazona ventralis). Procedures - Arthritis was experimentally induced via intra-articular injection of microcrystalline sodium urate suspension (MSU) into 1 intertarsal joint. Parrots were treated in a crossover design. Five treatments were compared as follows: meloxicam (4 dosages) at 0.05, 0.1, 0.5, and 1.0 mg/kg (IM, q 12 h, 3 times) and 0.03 mL of saline (0.9% NaCI) solution (IM, q 12 h, 3 times). The first treatment was given 6 hours following MSU administration. Lameness was assessed by use of a biomechanical perch to record weight-bearing load and a rotational perch to determine dexterity. Feces were collected to assay for occult blood. Results - Parrots treated with meloxicam at 1.0 mg/kg had significantly better return to normal (baseline) weight bearing on the arthritic pelvic limb, compared with control parrots or parrots treated with meloxicam at 0.05, 0.1, and 0.5 mg/kg. All fecal samples collected from parrots following induction of arthritis and treatment with meloxicam had negative results for occult blood. Conclusions and Clinical Relevance - Meloxicam administered at 1.0 mg/kg, IM, every 12 hours effectively relieved arthritic pain in parrots.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1471-1476 |
| Number of pages | 6 |
| Journal | American Journal of Veterinary Research |
| Volume | 70 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2009 |
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Analgesic effects of intramuscular administration of meloxicam in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis. / Cole, Gretchen A.; Paul-Murphy, Joanne R; Krugner-Higby, Lisa; Klauer, Julia M.; Medlin, Scott E.; Keuler, Nicholas S.; Sladky, Kurt K.
In: American Journal of Veterinary Research, Vol. 70, No. 12, 12.2009, p. 1471-1476.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analgesic effects of intramuscular administration of meloxicam in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis
AU - Cole, Gretchen A.
AU - Paul-Murphy, Joanne R
AU - Krugner-Higby, Lisa
AU - Klauer, Julia M.
AU - Medlin, Scott E.
AU - Keuler, Nicholas S.
AU - Sladky, Kurt K.
PY - 2009/12
Y1 - 2009/12
N2 - Objective - To evaluate the analgesic efficacy of meloxicam in parrots with experimentally induced arthritis, with extent of weight bearing and rotational perch walking used as outcome measures. Animals - 15 adult Hispaniolan parrots (Amazona ventralis). Procedures - Arthritis was experimentally induced via intra-articular injection of microcrystalline sodium urate suspension (MSU) into 1 intertarsal joint. Parrots were treated in a crossover design. Five treatments were compared as follows: meloxicam (4 dosages) at 0.05, 0.1, 0.5, and 1.0 mg/kg (IM, q 12 h, 3 times) and 0.03 mL of saline (0.9% NaCI) solution (IM, q 12 h, 3 times). The first treatment was given 6 hours following MSU administration. Lameness was assessed by use of a biomechanical perch to record weight-bearing load and a rotational perch to determine dexterity. Feces were collected to assay for occult blood. Results - Parrots treated with meloxicam at 1.0 mg/kg had significantly better return to normal (baseline) weight bearing on the arthritic pelvic limb, compared with control parrots or parrots treated with meloxicam at 0.05, 0.1, and 0.5 mg/kg. All fecal samples collected from parrots following induction of arthritis and treatment with meloxicam had negative results for occult blood. Conclusions and Clinical Relevance - Meloxicam administered at 1.0 mg/kg, IM, every 12 hours effectively relieved arthritic pain in parrots.
AB - Objective - To evaluate the analgesic efficacy of meloxicam in parrots with experimentally induced arthritis, with extent of weight bearing and rotational perch walking used as outcome measures. Animals - 15 adult Hispaniolan parrots (Amazona ventralis). Procedures - Arthritis was experimentally induced via intra-articular injection of microcrystalline sodium urate suspension (MSU) into 1 intertarsal joint. Parrots were treated in a crossover design. Five treatments were compared as follows: meloxicam (4 dosages) at 0.05, 0.1, 0.5, and 1.0 mg/kg (IM, q 12 h, 3 times) and 0.03 mL of saline (0.9% NaCI) solution (IM, q 12 h, 3 times). The first treatment was given 6 hours following MSU administration. Lameness was assessed by use of a biomechanical perch to record weight-bearing load and a rotational perch to determine dexterity. Feces were collected to assay for occult blood. Results - Parrots treated with meloxicam at 1.0 mg/kg had significantly better return to normal (baseline) weight bearing on the arthritic pelvic limb, compared with control parrots or parrots treated with meloxicam at 0.05, 0.1, and 0.5 mg/kg. All fecal samples collected from parrots following induction of arthritis and treatment with meloxicam had negative results for occult blood. Conclusions and Clinical Relevance - Meloxicam administered at 1.0 mg/kg, IM, every 12 hours effectively relieved arthritic pain in parrots.
UR - http://www.scopus.com/inward/record.url?scp=75149120209&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75149120209&partnerID=8YFLogxK
U2 - 10.2460/ajvr.70.12.1471
DO - 10.2460/ajvr.70.12.1471
M3 - Article
C2 - 19951118
AN - SCOPUS:75149120209
VL - 70
SP - 1471
EP - 1476
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
SN - 0002-9645
IS - 12
ER -