Analgesic effects of carprofen and liposome-encapsulated butorphanol tartrate in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis

Joanne R Paul-Murphy, Kurt K. Sladky, Lisa A. Krugner-Higby, Ben R. Stading, Julia M. Klauer, Nicholas S. Keuler, Carolyn S. Brown, Timothy D. Heath

Research output: Contribution to journalArticle

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Abstract

Objective - To evaluate the microcrystalline sodium urate (MSU) method for inducing arthritis in parrots and to compare the analgesic efficacy of long-acting liposome-encapsulated butorphanol (LEBT), carprofen, or a combination of both. Animals - 20 Hispaniolan parrots. Procedures - MSU was injected into a tibiotarsal-tarsometatarsal (intertarsal) joint to induce arthritis (time 0). Four treatments were compared (LEBT [15 mg/kg, SC] administered once at time 0; injections of carprofen [3 mg/kg, IM, q 12 h] starting at time 0; administration of LEBT plus carprofen; and a control treatment of saline [0.9% NaCl] solution). Weight load testing and behavioral scoring were conducted at 0, 2, 6, 26, and 30 hours. Results - Injection of MSU into the intertarsal joint induced arthritis, which resolved within 30 hours. Treatment with LEBT or LEBT plus carprofen resulted in significantly greater weight-bearing load on the limb with induced arthritis, compared with the control treatment. Treatment with carprofen alone caused a slight but nonsignificant improvement in weight-bearing load on the arthritic limb, compared with the control treatment. Behaviors associated with motor activity and weight bearing differed between the control and analgesic treatments. Conclusions and Clinical Relevance - Butorphanol was an effective treatment for pain associated with arthritis, but carprofen administered every 12 hours was insufficient. Injection of MSU to induce arthritis in a single joint was a good method for evaluating tonic pain in parrots, and measurement of the weight-bearing load was accurate for assessment of arthritic pain; however, behavioral changes associated with pain were subtle.

Original languageEnglish (US)
Pages (from-to)1201-1210
Number of pages10
JournalAmerican Journal of Veterinary Research
Volume70
Issue number10
DOIs
StatePublished - Oct 2009

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Amazona
Butorphanol
Parrots
butorphanol
analgesic effect
parrots
arthritis
Liposomes
Arthritis
Analgesics
Weight-Bearing
Uric Acid
pain
Tarsal Joints
sodium
analgesics
Therapeutics
injection
limbs (animal)
joints (animal)

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Analgesic effects of carprofen and liposome-encapsulated butorphanol tartrate in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis. / Paul-Murphy, Joanne R; Sladky, Kurt K.; Krugner-Higby, Lisa A.; Stading, Ben R.; Klauer, Julia M.; Keuler, Nicholas S.; Brown, Carolyn S.; Heath, Timothy D.

In: American Journal of Veterinary Research, Vol. 70, No. 10, 10.2009, p. 1201-1210.

Research output: Contribution to journalArticle

Paul-Murphy, Joanne R ; Sladky, Kurt K. ; Krugner-Higby, Lisa A. ; Stading, Ben R. ; Klauer, Julia M. ; Keuler, Nicholas S. ; Brown, Carolyn S. ; Heath, Timothy D. / Analgesic effects of carprofen and liposome-encapsulated butorphanol tartrate in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis. In: American Journal of Veterinary Research. 2009 ; Vol. 70, No. 10. pp. 1201-1210.
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abstract = "Objective - To evaluate the microcrystalline sodium urate (MSU) method for inducing arthritis in parrots and to compare the analgesic efficacy of long-acting liposome-encapsulated butorphanol (LEBT), carprofen, or a combination of both. Animals - 20 Hispaniolan parrots. Procedures - MSU was injected into a tibiotarsal-tarsometatarsal (intertarsal) joint to induce arthritis (time 0). Four treatments were compared (LEBT [15 mg/kg, SC] administered once at time 0; injections of carprofen [3 mg/kg, IM, q 12 h] starting at time 0; administration of LEBT plus carprofen; and a control treatment of saline [0.9{\%} NaCl] solution). Weight load testing and behavioral scoring were conducted at 0, 2, 6, 26, and 30 hours. Results - Injection of MSU into the intertarsal joint induced arthritis, which resolved within 30 hours. Treatment with LEBT or LEBT plus carprofen resulted in significantly greater weight-bearing load on the limb with induced arthritis, compared with the control treatment. Treatment with carprofen alone caused a slight but nonsignificant improvement in weight-bearing load on the arthritic limb, compared with the control treatment. Behaviors associated with motor activity and weight bearing differed between the control and analgesic treatments. Conclusions and Clinical Relevance - Butorphanol was an effective treatment for pain associated with arthritis, but carprofen administered every 12 hours was insufficient. Injection of MSU to induce arthritis in a single joint was a good method for evaluating tonic pain in parrots, and measurement of the weight-bearing load was accurate for assessment of arthritic pain; however, behavioral changes associated with pain were subtle.",
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AU - Krugner-Higby, Lisa A.

AU - Stading, Ben R.

AU - Klauer, Julia M.

AU - Keuler, Nicholas S.

AU - Brown, Carolyn S.

AU - Heath, Timothy D.

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