Dogs with previously untreated multicentric lymphoma were evaluated for the presence of the anaemia of chronic disease (ACD). Specimens were collected for histopathology, haematology, serum biochemistry, direct antiglobulin test (DAT), total serum iron concentration (TSI), total iron binding capacity (TIBC), bone marrow cytology, bone marrow iron determination and serum erythropoietin concentration (EPO). Thirty-five dogs were included in the study. The haematocrit of anaemic dogs (n = 15, mean ± standard error: 0.316 ± 0.0084 l/l, reference range 0.37-0.55 l/l) was significantly (p < 0.0001) less than non-anaemic dogs (n = 20, mean 0.446 ± 0.0128 l/l). Anaemic dogs had normal TSI (mean 23 ± 3.1 μmol/l, reference range 6-26 μmol/l), normal TIBC (mean 61 ± 2.70 μmol/l, reference range 50-69 μmol/l), increased serum ferritin concentration (mean 1104 ± 192 μg/l, reference range 80-800 μg/l), and normal serum EPO (mean 14.6 ± 1.88 U/l, reference range 5-15 U/l). Non-anaemic dogs had slightly increased TSI (mean 30 ± 2.8 μmol/l), normal TIBC (mean 60 ± 4.3 μmol/l), increased serum ferritin concentration (mean 1543 ± 302 μg/l), and normal serum EPO (mean 14.5 ± 1.64 U/l, n = 23). These values were not significantly different between groups (p > 0.1). Bone marrow iron stores were normal to increased in all dogs. These results do not support ACD as the cause of anaemia in dogs with lymphoma.
|Original language||English (US)|
|Number of pages||6|
|Journal||Comparative Clinical Pathology|
|State||Published - 1998|
ASJC Scopus subject areas
- Pathology and Forensic Medicine