Anaemia associated with canine lymphoma

M. D. Lucroy, Mary M Christopher, S. A. Kraegel, E. R. Simonson, B. R. Madewell

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Dogs with previously untreated multicentric lymphoma were evaluated for the presence of the anaemia of chronic disease (ACD). Specimens were collected for histopathology, haematology, serum biochemistry, direct antiglobulin test (DAT), total serum iron concentration (TSI), total iron binding capacity (TIBC), bone marrow cytology, bone marrow iron determination and serum erythropoietin concentration (EPO). Thirty-five dogs were included in the study. The haematocrit of anaemic dogs (n = 15, mean ± standard error: 0.316 ± 0.0084 l/l, reference range 0.37-0.55 l/l) was significantly (p < 0.0001) less than non-anaemic dogs (n = 20, mean 0.446 ± 0.0128 l/l). Anaemic dogs had normal TSI (mean 23 ± 3.1 μmol/l, reference range 6-26 μmol/l), normal TIBC (mean 61 ± 2.70 μmol/l, reference range 50-69 μmol/l), increased serum ferritin concentration (mean 1104 ± 192 μg/l, reference range 80-800 μg/l), and normal serum EPO (mean 14.6 ± 1.88 U/l, reference range 5-15 U/l). Non-anaemic dogs had slightly increased TSI (mean 30 ± 2.8 μmol/l), normal TIBC (mean 60 ± 4.3 μmol/l), increased serum ferritin concentration (mean 1543 ± 302 μg/l), and normal serum EPO (mean 14.5 ± 1.64 U/l, n = 23). These values were not significantly different between groups (p > 0.1). Bone marrow iron stores were normal to increased in all dogs. These results do not support ACD as the cause of anaemia in dogs with lymphoma.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalComparative Clinical Pathology
Volume8
Issue number1
StatePublished - 1998

Fingerprint

Canidae
Anemia
Lymphoma
Dogs
Iron
Bone Marrow
Chronic Disease
Serum
Coombs Test
Hematology
Erythropoietin
Hematocrit
Biochemistry
Cell Biology
Reference Values

Keywords

  • Anaemia
  • Canine
  • Iron
  • Lymphoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Lucroy, M. D., Christopher, M. M., Kraegel, S. A., Simonson, E. R., & Madewell, B. R. (1998). Anaemia associated with canine lymphoma. Comparative Clinical Pathology, 8(1), 1-6.

Anaemia associated with canine lymphoma. / Lucroy, M. D.; Christopher, Mary M; Kraegel, S. A.; Simonson, E. R.; Madewell, B. R.

In: Comparative Clinical Pathology, Vol. 8, No. 1, 1998, p. 1-6.

Research output: Contribution to journalArticle

Lucroy, MD, Christopher, MM, Kraegel, SA, Simonson, ER & Madewell, BR 1998, 'Anaemia associated with canine lymphoma', Comparative Clinical Pathology, vol. 8, no. 1, pp. 1-6.
Lucroy MD, Christopher MM, Kraegel SA, Simonson ER, Madewell BR. Anaemia associated with canine lymphoma. Comparative Clinical Pathology. 1998;8(1):1-6.
Lucroy, M. D. ; Christopher, Mary M ; Kraegel, S. A. ; Simonson, E. R. ; Madewell, B. R. / Anaemia associated with canine lymphoma. In: Comparative Clinical Pathology. 1998 ; Vol. 8, No. 1. pp. 1-6.
@article{c4680376228d4a64b3580468326ca468,
title = "Anaemia associated with canine lymphoma",
abstract = "Dogs with previously untreated multicentric lymphoma were evaluated for the presence of the anaemia of chronic disease (ACD). Specimens were collected for histopathology, haematology, serum biochemistry, direct antiglobulin test (DAT), total serum iron concentration (TSI), total iron binding capacity (TIBC), bone marrow cytology, bone marrow iron determination and serum erythropoietin concentration (EPO). Thirty-five dogs were included in the study. The haematocrit of anaemic dogs (n = 15, mean ± standard error: 0.316 ± 0.0084 l/l, reference range 0.37-0.55 l/l) was significantly (p < 0.0001) less than non-anaemic dogs (n = 20, mean 0.446 ± 0.0128 l/l). Anaemic dogs had normal TSI (mean 23 ± 3.1 μmol/l, reference range 6-26 μmol/l), normal TIBC (mean 61 ± 2.70 μmol/l, reference range 50-69 μmol/l), increased serum ferritin concentration (mean 1104 ± 192 μg/l, reference range 80-800 μg/l), and normal serum EPO (mean 14.6 ± 1.88 U/l, reference range 5-15 U/l). Non-anaemic dogs had slightly increased TSI (mean 30 ± 2.8 μmol/l), normal TIBC (mean 60 ± 4.3 μmol/l), increased serum ferritin concentration (mean 1543 ± 302 μg/l), and normal serum EPO (mean 14.5 ± 1.64 U/l, n = 23). These values were not significantly different between groups (p > 0.1). Bone marrow iron stores were normal to increased in all dogs. These results do not support ACD as the cause of anaemia in dogs with lymphoma.",
keywords = "Anaemia, Canine, Iron, Lymphoma",
author = "Lucroy, {M. D.} and Christopher, {Mary M} and Kraegel, {S. A.} and Simonson, {E. R.} and Madewell, {B. R.}",
year = "1998",
language = "English (US)",
volume = "8",
pages = "1--6",
journal = "Comparative Clinical Pathology",
issn = "1618-5641",
publisher = "Springer London",
number = "1",

}

TY - JOUR

T1 - Anaemia associated with canine lymphoma

AU - Lucroy, M. D.

AU - Christopher, Mary M

AU - Kraegel, S. A.

AU - Simonson, E. R.

AU - Madewell, B. R.

PY - 1998

Y1 - 1998

N2 - Dogs with previously untreated multicentric lymphoma were evaluated for the presence of the anaemia of chronic disease (ACD). Specimens were collected for histopathology, haematology, serum biochemistry, direct antiglobulin test (DAT), total serum iron concentration (TSI), total iron binding capacity (TIBC), bone marrow cytology, bone marrow iron determination and serum erythropoietin concentration (EPO). Thirty-five dogs were included in the study. The haematocrit of anaemic dogs (n = 15, mean ± standard error: 0.316 ± 0.0084 l/l, reference range 0.37-0.55 l/l) was significantly (p < 0.0001) less than non-anaemic dogs (n = 20, mean 0.446 ± 0.0128 l/l). Anaemic dogs had normal TSI (mean 23 ± 3.1 μmol/l, reference range 6-26 μmol/l), normal TIBC (mean 61 ± 2.70 μmol/l, reference range 50-69 μmol/l), increased serum ferritin concentration (mean 1104 ± 192 μg/l, reference range 80-800 μg/l), and normal serum EPO (mean 14.6 ± 1.88 U/l, reference range 5-15 U/l). Non-anaemic dogs had slightly increased TSI (mean 30 ± 2.8 μmol/l), normal TIBC (mean 60 ± 4.3 μmol/l), increased serum ferritin concentration (mean 1543 ± 302 μg/l), and normal serum EPO (mean 14.5 ± 1.64 U/l, n = 23). These values were not significantly different between groups (p > 0.1). Bone marrow iron stores were normal to increased in all dogs. These results do not support ACD as the cause of anaemia in dogs with lymphoma.

AB - Dogs with previously untreated multicentric lymphoma were evaluated for the presence of the anaemia of chronic disease (ACD). Specimens were collected for histopathology, haematology, serum biochemistry, direct antiglobulin test (DAT), total serum iron concentration (TSI), total iron binding capacity (TIBC), bone marrow cytology, bone marrow iron determination and serum erythropoietin concentration (EPO). Thirty-five dogs were included in the study. The haematocrit of anaemic dogs (n = 15, mean ± standard error: 0.316 ± 0.0084 l/l, reference range 0.37-0.55 l/l) was significantly (p < 0.0001) less than non-anaemic dogs (n = 20, mean 0.446 ± 0.0128 l/l). Anaemic dogs had normal TSI (mean 23 ± 3.1 μmol/l, reference range 6-26 μmol/l), normal TIBC (mean 61 ± 2.70 μmol/l, reference range 50-69 μmol/l), increased serum ferritin concentration (mean 1104 ± 192 μg/l, reference range 80-800 μg/l), and normal serum EPO (mean 14.6 ± 1.88 U/l, reference range 5-15 U/l). Non-anaemic dogs had slightly increased TSI (mean 30 ± 2.8 μmol/l), normal TIBC (mean 60 ± 4.3 μmol/l), increased serum ferritin concentration (mean 1543 ± 302 μg/l), and normal serum EPO (mean 14.5 ± 1.64 U/l, n = 23). These values were not significantly different between groups (p > 0.1). Bone marrow iron stores were normal to increased in all dogs. These results do not support ACD as the cause of anaemia in dogs with lymphoma.

KW - Anaemia

KW - Canine

KW - Iron

KW - Lymphoma

UR - http://www.scopus.com/inward/record.url?scp=54749151814&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54749151814&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:54749151814

VL - 8

SP - 1

EP - 6

JO - Comparative Clinical Pathology

JF - Comparative Clinical Pathology

SN - 1618-5641

IS - 1

ER -