An unusual distribution of the kdr gene among populations of Anopheles gambiae on the island of Bioko, Equatorial Guinea

L. J. Reimer, F. Tripet, M. Slotman, A. Spielman, E. Fondjo, Gregory C Lanzaro

Research output: Contribution to journalArticle

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Abstract

In West Africa, Anopheles gambiae exists in discrete subpopulations known as the M and S molecular forms. Although these forms occur in sympatry, pyrethroid knock-down resistance (kdr) is strongly associated with the S molecular form. On the island of Bioko, Equatorial Guinea we found high frequencies of the kdr mutation in M form individuals (55.8%) and a complete absence of kdr in the S form. We also report the absence of the kdr allele in M and S specimens from the harbour town of Tiko in Cameroon, representing the nearest continental population to Bioko. The kdr allele had previously been reported as absent in populations of An. gambiae on Bioko. Contrary to earlier reports, sequencing of intron-1 of this sodium channel gene revealed no fixed differences between M form resistant and susceptible individuals. The mutation may have recently arisen independently in the M form on Bioko due to recent and intensive pyrethroid application.

Original languageEnglish (US)
Pages (from-to)683-688
Number of pages6
JournalInsect Molecular Biology
Volume14
Issue number6
DOIs
StatePublished - Dec 2005

Fingerprint

Equatorial Guinea
pesticide resistance
Gene Knockdown Techniques
Anopheles gambiae
Pyrethrins
Islands
Genes
Alleles
Sympatry
Cameroon
Mutation
Western Africa
Sodium Channels
Ports and harbors
Introns
Population
pyrethrins
genes
alleles
mutation

Keywords

  • Anopheles gambiae
  • Bioko
  • kdr
  • Molecular forms

ASJC Scopus subject areas

  • Insect Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

An unusual distribution of the kdr gene among populations of Anopheles gambiae on the island of Bioko, Equatorial Guinea. / Reimer, L. J.; Tripet, F.; Slotman, M.; Spielman, A.; Fondjo, E.; Lanzaro, Gregory C.

In: Insect Molecular Biology, Vol. 14, No. 6, 12.2005, p. 683-688.

Research output: Contribution to journalArticle

Reimer, L. J. ; Tripet, F. ; Slotman, M. ; Spielman, A. ; Fondjo, E. ; Lanzaro, Gregory C. / An unusual distribution of the kdr gene among populations of Anopheles gambiae on the island of Bioko, Equatorial Guinea. In: Insect Molecular Biology. 2005 ; Vol. 14, No. 6. pp. 683-688.
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