An outbreak of equine botulism type A associated with feeding grass clippings

Stephanie R. Ostrowski, Steven V. Kubiski, Joanie Palmero, Christopher M. Reilly, Jamie K. Higgins, Sheri Cook-Cronin, Snehal N. Tawde, Beate Crossley, Paula Yant, Ray Cazarez, Francisco A Uzal

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In September 2010, an outbreak of type A botulism involved 4 horses in northern California that were fed grass clippings obtained from a nearby park. All 4 animals developed a progressive flaccid paralysis syndrome clinically consistent with exposure to preformed Clostridium botulinum neurotoxin (BoNT). Within 48 hr of consuming the grass clippings, all 4 horses showed marked cervical weakness (inability to raise their heads to a normal position) and died or were euthanized within 96 hr. One horse was submitted for diagnostic examination and subsequent necropsy. At necropsy, extensive edema was observed in areas of the nuchal ligament and inguinal fascia. A sample of the grass clippings tested positive for preformed BoNT type A by the mouse bioassay test. Emphasis should be placed on early case recognition, rapid initiation of treatment with the trivalent antitoxin product, and preventing exposure to BoNT in spoiled forages.

Original languageEnglish (US)
Pages (from-to)601-603
Number of pages3
JournalJournal of Veterinary Diagnostic Investigation
Volume24
Issue number3
DOIs
StatePublished - May 2012

Fingerprint

botulinum toxin
Botulism
botulism
Poaceae
Horses
Disease Outbreaks
Neurotoxins
grasses
horses
necropsy
Clostridium botulinum
antitoxins
Antitoxins
fascia
Type A Botulinum Toxins
Groin
Fascia
paralysis
ligaments
Ligaments

Keywords

  • Botulism
  • Clostridium botulinum
  • grass
  • neurotoxin
  • type A

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Ostrowski, S. R., Kubiski, S. V., Palmero, J., Reilly, C. M., Higgins, J. K., Cook-Cronin, S., ... Uzal, F. A. (2012). An outbreak of equine botulism type A associated with feeding grass clippings. Journal of Veterinary Diagnostic Investigation, 24(3), 601-603. https://doi.org/10.1177/1040638712440987

An outbreak of equine botulism type A associated with feeding grass clippings. / Ostrowski, Stephanie R.; Kubiski, Steven V.; Palmero, Joanie; Reilly, Christopher M.; Higgins, Jamie K.; Cook-Cronin, Sheri; Tawde, Snehal N.; Crossley, Beate; Yant, Paula; Cazarez, Ray; Uzal, Francisco A.

In: Journal of Veterinary Diagnostic Investigation, Vol. 24, No. 3, 05.2012, p. 601-603.

Research output: Contribution to journalArticle

Ostrowski, SR, Kubiski, SV, Palmero, J, Reilly, CM, Higgins, JK, Cook-Cronin, S, Tawde, SN, Crossley, B, Yant, P, Cazarez, R & Uzal, FA 2012, 'An outbreak of equine botulism type A associated with feeding grass clippings', Journal of Veterinary Diagnostic Investigation, vol. 24, no. 3, pp. 601-603. https://doi.org/10.1177/1040638712440987
Ostrowski SR, Kubiski SV, Palmero J, Reilly CM, Higgins JK, Cook-Cronin S et al. An outbreak of equine botulism type A associated with feeding grass clippings. Journal of Veterinary Diagnostic Investigation. 2012 May;24(3):601-603. https://doi.org/10.1177/1040638712440987
Ostrowski, Stephanie R. ; Kubiski, Steven V. ; Palmero, Joanie ; Reilly, Christopher M. ; Higgins, Jamie K. ; Cook-Cronin, Sheri ; Tawde, Snehal N. ; Crossley, Beate ; Yant, Paula ; Cazarez, Ray ; Uzal, Francisco A. / An outbreak of equine botulism type A associated with feeding grass clippings. In: Journal of Veterinary Diagnostic Investigation. 2012 ; Vol. 24, No. 3. pp. 601-603.
@article{2eb3647a6dab49c498c41b677bdeeaef,
title = "An outbreak of equine botulism type A associated with feeding grass clippings",
abstract = "In September 2010, an outbreak of type A botulism involved 4 horses in northern California that were fed grass clippings obtained from a nearby park. All 4 animals developed a progressive flaccid paralysis syndrome clinically consistent with exposure to preformed Clostridium botulinum neurotoxin (BoNT). Within 48 hr of consuming the grass clippings, all 4 horses showed marked cervical weakness (inability to raise their heads to a normal position) and died or were euthanized within 96 hr. One horse was submitted for diagnostic examination and subsequent necropsy. At necropsy, extensive edema was observed in areas of the nuchal ligament and inguinal fascia. A sample of the grass clippings tested positive for preformed BoNT type A by the mouse bioassay test. Emphasis should be placed on early case recognition, rapid initiation of treatment with the trivalent antitoxin product, and preventing exposure to BoNT in spoiled forages.",
keywords = "Botulism, Clostridium botulinum, grass, neurotoxin, type A",
author = "Ostrowski, {Stephanie R.} and Kubiski, {Steven V.} and Joanie Palmero and Reilly, {Christopher M.} and Higgins, {Jamie K.} and Sheri Cook-Cronin and Tawde, {Snehal N.} and Beate Crossley and Paula Yant and Ray Cazarez and Uzal, {Francisco A}",
year = "2012",
month = "5",
doi = "10.1177/1040638712440987",
language = "English (US)",
volume = "24",
pages = "601--603",
journal = "Journal of Veterinary Diagnostic Investigation",
issn = "1040-6387",
publisher = "American Association of Veterinary Laboratory Diagnosticians",
number = "3",

}

TY - JOUR

T1 - An outbreak of equine botulism type A associated with feeding grass clippings

AU - Ostrowski, Stephanie R.

AU - Kubiski, Steven V.

AU - Palmero, Joanie

AU - Reilly, Christopher M.

AU - Higgins, Jamie K.

AU - Cook-Cronin, Sheri

AU - Tawde, Snehal N.

AU - Crossley, Beate

AU - Yant, Paula

AU - Cazarez, Ray

AU - Uzal, Francisco A

PY - 2012/5

Y1 - 2012/5

N2 - In September 2010, an outbreak of type A botulism involved 4 horses in northern California that were fed grass clippings obtained from a nearby park. All 4 animals developed a progressive flaccid paralysis syndrome clinically consistent with exposure to preformed Clostridium botulinum neurotoxin (BoNT). Within 48 hr of consuming the grass clippings, all 4 horses showed marked cervical weakness (inability to raise their heads to a normal position) and died or were euthanized within 96 hr. One horse was submitted for diagnostic examination and subsequent necropsy. At necropsy, extensive edema was observed in areas of the nuchal ligament and inguinal fascia. A sample of the grass clippings tested positive for preformed BoNT type A by the mouse bioassay test. Emphasis should be placed on early case recognition, rapid initiation of treatment with the trivalent antitoxin product, and preventing exposure to BoNT in spoiled forages.

AB - In September 2010, an outbreak of type A botulism involved 4 horses in northern California that were fed grass clippings obtained from a nearby park. All 4 animals developed a progressive flaccid paralysis syndrome clinically consistent with exposure to preformed Clostridium botulinum neurotoxin (BoNT). Within 48 hr of consuming the grass clippings, all 4 horses showed marked cervical weakness (inability to raise their heads to a normal position) and died or were euthanized within 96 hr. One horse was submitted for diagnostic examination and subsequent necropsy. At necropsy, extensive edema was observed in areas of the nuchal ligament and inguinal fascia. A sample of the grass clippings tested positive for preformed BoNT type A by the mouse bioassay test. Emphasis should be placed on early case recognition, rapid initiation of treatment with the trivalent antitoxin product, and preventing exposure to BoNT in spoiled forages.

KW - Botulism

KW - Clostridium botulinum

KW - grass

KW - neurotoxin

KW - type A

UR - http://www.scopus.com/inward/record.url?scp=84860205387&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860205387&partnerID=8YFLogxK

U2 - 10.1177/1040638712440987

DO - 10.1177/1040638712440987

M3 - Article

C2 - 22529134

AN - SCOPUS:84860205387

VL - 24

SP - 601

EP - 603

JO - Journal of Veterinary Diagnostic Investigation

JF - Journal of Veterinary Diagnostic Investigation

SN - 1040-6387

IS - 3

ER -