An outbreak of cecal mucosal hyperplasia in hamsters

Stephen W Barthold, R. O. Jacoby, G. J. Pucak

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Cecal mucosal hyperplasia associated with diarrhea, runting, and high mortality in suckling and weanling hamsters occurred as a natural disease outbreak in a production colony. Young hamsters were runted, and their perineal hair was stained and matted with liquid feces. Their ceca were thickened, contracted, congested, and had scant luminal content. There were severe hyperplasia of cecal crypts, accompanied by increased mitotic activity, inflammation, and focal mucosal erosion. A variety of bacteria was isolated, but none was considered pathogenic. No relationship of cecal hyperplasia to transmissible ileal hyperplasia of hamsters was found. Hyperimmune serum from hamsters with transmissible ileal hyperplasia did not react by immunofluorescence against hyperplastic cecal mucosa. Electron microscopy did not reveal a causative agent. Transmission attempts have been unsuccessful. Cecal mucosal hyperplasia is apparently a newly discovered disease entity in hamsters with the clinical sign of diarrhea.

Original languageEnglish (US)
Title of host publicationLaboratory Animal Science
Pages723-727
Number of pages5
Volume28
Edition6
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Barthold, S. W., Jacoby, R. O., & Pucak, G. J. (1978). An outbreak of cecal mucosal hyperplasia in hamsters. In Laboratory Animal Science (6 ed., Vol. 28, pp. 723-727)