Abstract
Vascular permeability as a function of age was evaluated quantitatively and morphologically in skin of fetal Rhesus monkeys given vasoactive mediators. The response was examined at 90, 120 or 150 days of gestation or at birth and compared to the response of yearling Rhesus monkeys. Skin sites were challenged with histamine, compound 48/80 or bradykinin. Evans' blue and horseradish peroxidase were used as markers of vascular integrity. Evans' blue was quantified spectrophotometrically. Vascular permeability during fetal life was depressed. Fetal venules and capillaries had poorly formed basement membranes, an abundance of microfilaments within endothelial cells, occasional electron dense endothelial cells and infrequent deposits of extravascular peroxidase.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 358-366 |
| Number of pages | 9 |
| Journal | Veterinary Pathology |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1978 |
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An ontogenic study of the acute inflammatory response in the rhesus monkey. II. The mediation of increased vascular permeability by histamine, compound 48/80 and bradykinin. / Schwartz, L. W.; Osburn, Bennie.
In: Veterinary Pathology, Vol. 15, No. 3, 01.01.1978, p. 358-366.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An ontogenic study of the acute inflammatory response in the rhesus monkey. II. The mediation of increased vascular permeability by histamine, compound 48/80 and bradykinin
AU - Schwartz, L. W.
AU - Osburn, Bennie
PY - 1978/1/1
Y1 - 1978/1/1
N2 - Vascular permeability as a function of age was evaluated quantitatively and morphologically in skin of fetal Rhesus monkeys given vasoactive mediators. The response was examined at 90, 120 or 150 days of gestation or at birth and compared to the response of yearling Rhesus monkeys. Skin sites were challenged with histamine, compound 48/80 or bradykinin. Evans' blue and horseradish peroxidase were used as markers of vascular integrity. Evans' blue was quantified spectrophotometrically. Vascular permeability during fetal life was depressed. Fetal venules and capillaries had poorly formed basement membranes, an abundance of microfilaments within endothelial cells, occasional electron dense endothelial cells and infrequent deposits of extravascular peroxidase.
AB - Vascular permeability as a function of age was evaluated quantitatively and morphologically in skin of fetal Rhesus monkeys given vasoactive mediators. The response was examined at 90, 120 or 150 days of gestation or at birth and compared to the response of yearling Rhesus monkeys. Skin sites were challenged with histamine, compound 48/80 or bradykinin. Evans' blue and horseradish peroxidase were used as markers of vascular integrity. Evans' blue was quantified spectrophotometrically. Vascular permeability during fetal life was depressed. Fetal venules and capillaries had poorly formed basement membranes, an abundance of microfilaments within endothelial cells, occasional electron dense endothelial cells and infrequent deposits of extravascular peroxidase.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018104498&partnerID=8YFLogxK
U2 - 10.1177/030098587801500311
DO - 10.1177/030098587801500311
M3 - Article
VL - 15
SP - 358
EP - 366
JO - Veterinary Pathology
JF - Veterinary Pathology
SN - 0300-9858
IS - 3
ER -