An investigation of the action of neutral Protamine hagedorn human analogue insulin in dogs with naturally occurring diabetes mellitus

Carrie Palm, R. C. Boston, K. R. Refsal, R. S. Hess

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Neutral Protamine Hagedorn human analogue insulin (Humulin N) is commonly used for treatment of canine diabetes mellitus (DM). However, blood glucose and serum insulin concentrations in Humulin N-treated dogs with naturally occurring DM have not been reported. Objective: To investigate blood glucose and serum insulin concentrations in the clinical setting of client-owned Humulin N-treated dogs with naturally occurring, well-regulated DM. Animals: Ten client-owned dogs with naturally occurring, well-regulated DM. Methods: In this clinical study, blood glucose and serum insulin concentrations were measured when dogs received food and insulin (T 0), at approximately every half hour for the next 2 hours, and then approximately every 2 hours for an additional 8 hours. Insulin duration of action was defined as the number of hours from T 0 to the lowest blood glucose concentration and until blood glucose concentration returned to an interpolated value of 70% of basal blood glucose concentration (Glucose b). Results: Mean percent of insulin-induced blood glucose suppression was 49.9 ± 17.1% (median, 46%; range, 29-78%). Insulin duration of action ranged from 4 to 10 hours. Blood glucose concentration increased initially and returned to Glucose b within 0.6-2.2 hours after T 0 in 5 dogs. This initial blood glucose surge then was followed by blood glucose suppression in all 5 dogs. Conclusions and Clinical Importance: These results suggest that Humulin N administered SC twice daily is an effective mode of treatment for dogs with naturally occurring DM. Postprandial hyperglycemia is present in some well-regulated diabetic dogs treated with Humulin N.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalJournal of Veterinary Internal Medicine
Volume23
Issue number1
DOIs
StatePublished - Jan 2009
Externally publishedYes

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protamines
Protamines
diabetes mellitus
blood glucose
Blood Glucose
Diabetes Mellitus
insulin
Dogs
Insulin
dogs
blood serum
Serum
pet foods
Glucose
glucose
duration
hyperglycemia
Hyperglycemia
Canidae
clinical trials

Keywords

  • Canine
  • Endocrine pancreas
  • Glucose
  • Hyperglycemia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

An investigation of the action of neutral Protamine hagedorn human analogue insulin in dogs with naturally occurring diabetes mellitus. / Palm, Carrie; Boston, R. C.; Refsal, K. R.; Hess, R. S.

In: Journal of Veterinary Internal Medicine, Vol. 23, No. 1, 01.2009, p. 50-55.

Research output: Contribution to journalArticle

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