An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease

Lidia Sarro, Nirubol Tosakulwong, Christopher G. Schwarz, Jonathan Graff-Radford, Scott A. Przybelski, Timothy G. Lesnick, Samantha M. Zuk, Robert I. Reid, Mekala R. Raman, Bradley F. Boeve, Tanis J. Ferman, David S. Knopman, Giancarlo Comi, Massimo Filippi, Melissa E. Murray, Joseph E. Parisi, Dennis W. Dickson, Ronald C. Petersen, Clifford R. Jack, Kejal Kantarci

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Introduction: Cerebrovascular lesions on MRI are common in Alzheimer's disease (AD) dementia, but less is known about their frequency and impact on dementia with Lewy bodies (DLB). Methods: White-matter hyperintensities (WMHs) and infarcts on MRI were assessed in consecutive DLB (n = 81) and AD dementia (n = 240) patients and compared to age-matched and sex-matched cognitively normal subjects (CN) from a population-based cohort. Results: DLB had higher WMH volume compared to CN, and WMH volume was higher in the occipital and posterior periventricular regions in DLB compared to AD. Higher WMH volume was associated with history of cardiovascular disease and diabetes but not with clinical disease severity in DLB. Frequency of infarcts in DLB was not different from CN and AD dementia. Discussion: In DLB, WMH volume is higher than AD and CN and appears to be primarily associated with history of vascular disease.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2016
Externally publishedYes

Fingerprint

Lewy Body Disease
Alzheimer Disease
Vascular Diseases
Cardiovascular Diseases
White Matter

Keywords

  • Alzheimer's disease
  • Cerebrovascular disease
  • Dementia with Lewy bodies
  • Infarcts
  • MRI
  • Sex differences
  • White matter hyperintensities

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Sarro, L., Tosakulwong, N., Schwarz, C. G., Graff-Radford, J., Przybelski, S. A., Lesnick, T. G., ... Kantarci, K. (Accepted/In press). An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2016.07.003

An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease. / Sarro, Lidia; Tosakulwong, Nirubol; Schwarz, Christopher G.; Graff-Radford, Jonathan; Przybelski, Scott A.; Lesnick, Timothy G.; Zuk, Samantha M.; Reid, Robert I.; Raman, Mekala R.; Boeve, Bradley F.; Ferman, Tanis J.; Knopman, David S.; Comi, Giancarlo; Filippi, Massimo; Murray, Melissa E.; Parisi, Joseph E.; Dickson, Dennis W.; Petersen, Ronald C.; Jack, Clifford R.; Kantarci, Kejal.

In: Alzheimer's and Dementia, 2016.

Research output: Contribution to journalArticle

Sarro, L, Tosakulwong, N, Schwarz, CG, Graff-Radford, J, Przybelski, SA, Lesnick, TG, Zuk, SM, Reid, RI, Raman, MR, Boeve, BF, Ferman, TJ, Knopman, DS, Comi, G, Filippi, M, Murray, ME, Parisi, JE, Dickson, DW, Petersen, RC, Jack, CR & Kantarci, K 2016, 'An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease', Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2016.07.003
Sarro, Lidia ; Tosakulwong, Nirubol ; Schwarz, Christopher G. ; Graff-Radford, Jonathan ; Przybelski, Scott A. ; Lesnick, Timothy G. ; Zuk, Samantha M. ; Reid, Robert I. ; Raman, Mekala R. ; Boeve, Bradley F. ; Ferman, Tanis J. ; Knopman, David S. ; Comi, Giancarlo ; Filippi, Massimo ; Murray, Melissa E. ; Parisi, Joseph E. ; Dickson, Dennis W. ; Petersen, Ronald C. ; Jack, Clifford R. ; Kantarci, Kejal. / An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease. In: Alzheimer's and Dementia. 2016.
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AU - Tosakulwong, Nirubol

AU - Schwarz, Christopher G.

AU - Graff-Radford, Jonathan

AU - Przybelski, Scott A.

AU - Lesnick, Timothy G.

AU - Zuk, Samantha M.

AU - Reid, Robert I.

AU - Raman, Mekala R.

AU - Boeve, Bradley F.

AU - Ferman, Tanis J.

AU - Knopman, David S.

AU - Comi, Giancarlo

AU - Filippi, Massimo

AU - Murray, Melissa E.

AU - Parisi, Joseph E.

AU - Dickson, Dennis W.

AU - Petersen, Ronald C.

AU - Jack, Clifford R.

AU - Kantarci, Kejal

PY - 2016

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N2 - Introduction: Cerebrovascular lesions on MRI are common in Alzheimer's disease (AD) dementia, but less is known about their frequency and impact on dementia with Lewy bodies (DLB). Methods: White-matter hyperintensities (WMHs) and infarcts on MRI were assessed in consecutive DLB (n = 81) and AD dementia (n = 240) patients and compared to age-matched and sex-matched cognitively normal subjects (CN) from a population-based cohort. Results: DLB had higher WMH volume compared to CN, and WMH volume was higher in the occipital and posterior periventricular regions in DLB compared to AD. Higher WMH volume was associated with history of cardiovascular disease and diabetes but not with clinical disease severity in DLB. Frequency of infarcts in DLB was not different from CN and AD dementia. Discussion: In DLB, WMH volume is higher than AD and CN and appears to be primarily associated with history of vascular disease.

AB - Introduction: Cerebrovascular lesions on MRI are common in Alzheimer's disease (AD) dementia, but less is known about their frequency and impact on dementia with Lewy bodies (DLB). Methods: White-matter hyperintensities (WMHs) and infarcts on MRI were assessed in consecutive DLB (n = 81) and AD dementia (n = 240) patients and compared to age-matched and sex-matched cognitively normal subjects (CN) from a population-based cohort. Results: DLB had higher WMH volume compared to CN, and WMH volume was higher in the occipital and posterior periventricular regions in DLB compared to AD. Higher WMH volume was associated with history of cardiovascular disease and diabetes but not with clinical disease severity in DLB. Frequency of infarcts in DLB was not different from CN and AD dementia. Discussion: In DLB, WMH volume is higher than AD and CN and appears to be primarily associated with history of vascular disease.

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